Polymedicine: Known and Unknown Drug Interactions
Polymedicine: Known and Unknown Drug Interactions
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综合医学：已知和未知的药物相互作用
DOI：
10.1111/j.1532-5415.1982.tb01363.x
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发表时间：
1982
影响因子：
6.3
通讯作者：
L. Block
中科院分区：
文献类型：
--
作者：
L. Block
尽管经过了15年多的广泛审查，药物不良相互作用，特别是在老年人中，仍然是临床医生的一个问题。建议采用双管齐下的方法来应对药物相互作用：检测或避免已知的药物相互作用;以及预测和表征迄今未知的相互作用。前一种方法得到了关于受试者的关键参考来源和药物相互作用筛选辅助工具（如药物相互作用警报列表或旋转药物圆盘）的帮助。计算机变得越来越重要，不仅用于检测潜在的药物相互作用，而且用于描绘药物治疗方案。最终，计算机可以用来预测的基础上的物理化学，药代动力学和药效学数据的相互作用。就目前而言，广泛的流行病学研究项目可以帮助找出相互作用。如果要处理药物相互作用问题，对此类项目数据库的有限访问权限要求准备充分和消息灵通的观察员高度怀疑。
Despite more than 15 years of extensive scrutiny, adverse drug interactions, especially in the elderly, remain a problem for the clinician. A two‐pronged approach is suggested to contend with drug interactions: detection or avoidance of known drug interactions; and predictions and characterization of hitherto unknown interactions. The former approach is aided by critical reference sources on the subject and the use of drug interaction screening aids such as drug interactions alert lists or rotating drug discs. Computers are becoming increasingly important not only for the detection of potential drug interactions but also for the delineation of drug therapy options. Ultimately, computers can be used to predict interactions on the basis of physiochemical, pharmacokinetic, and pharmacodynamic data. For the present, extensive epidemiologic research programs can serve to ferret out interactions. Limited accessibility to such program data bases mandates a high index of suspicion in prepared and well‐informed observers if the drug interaction problem is to be dealt with.