Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease
Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease
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DOI：
10.1080/02713680701586409
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Tsubota, Kazuo
中科院分区：
文献类型：
--
作者：
Kamoi, Mizuka;Ogawa, Yoko;Tsubota, Kazuo
目的：目的探讨异基因造血干细胞移植（HSCT）后自发性泪点阻塞（SLPO）的临床特点。泪点的情况，干眼症的严重程度，睑板腺分泌，以及是否存在系统性慢性移植物抗宿主病（cGVHD）与或不SLPO通过回顾性图表review.Results：在119个收件人，SLPO被诊断为8。所有HSCT后发生SLPO的患者均存在睑板腺功能障碍（MGD）、干眼和系统性cGVHD。SLPO受者中干眼症、MGD和全身cGVHD患者的百分比显著高于非SLPO受者（分别为p <0.0013、p <0.00015、p <0.0008）。结论：SLPO是眼部cGVHD的临床表现，并且可能是HSCT后干眼症和全身cGVHD严重程度的指标。
Purpose: To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT).Methods: One hundred nineteen recipients after HSCT who visited Keio University between 2001 and 2004 were examined. The condition of the lacrimal punctum, severity of dry eye, meibomian gland secretion, and presence of systemic chronic graft-versus-host disease (cGVHD) were determined with or without SLPO by retrospective chart review.Results: Among the 119 recipients, SLPO was diagnosed in 8. All the patients with SLPO after HSCT had meibomian gland dysfunction (MGD), dry eye, and systemic cGVHD. The percentage of patients with dry eye, MGD, and systemic cGVHD were significantly higher in recipients with SLPO than non-SLPO recipients ( p < 0.0013, p < 0.00015, p < 0.0008, respectively).Conclusions: SLPO is a clinical presentation of ocular cGVHD and may be an indicator of the severity of dry eye and systemic cGVHD after HSCT.