A Hyperkinetic Redox Sensor Drives Flies to Sleep.
A Hyperkinetic Redox Sensor Drives Flies to Sleep.
复制标题
超动力氧化还原传感器促使果蝇入睡。
DOI：
10.1016/j.tins.2019.05.007
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发表时间：
2019
影响因子：
15.9
通讯作者：
Takahashi,JosephS
中科院分区：
文献类型：
--
作者：
Xu,Pin;Cox,KimberlyH;Takahashi,JosephS
几种不同的钾离子通道调节果蝇脑内促进睡眠神经元的活动，但这些通道的调节机制还不完全清楚。最近的一项研究（Kempfet等人，Nature，2019）发现钾通道亚基之一Hyperkinetic改变了睡眠促进神经元对NADPH氧化的反应。这些发现首次将细胞氧化还原状态和线粒体代谢直接与睡眠联系起来。
Several different potassium channels modulate the activity of sleep-promoting neurons in theDrosophilabrain, but the regulation of these channels is not completely understood. A recent study (Kempfet al.,Nature,2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.