Trends in head and neck cancer incidence in relation to smoking prevalence - An emerging epidemic of human papillomavirus-associated cancers?
Trends in head and neck cancer incidence in relation to smoking prevalence - An emerging epidemic of human papillomavirus-associated cancers?
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DOI：
10.1002/cncr.22963
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发表时间：
2007-10-01
期刊：
影响因子：
6.2
通讯作者：
Cinciripini, Paul M.
中科院分区：
文献类型：
--
作者：
Sturgis, Erich M.;Cinciripini, Paul M.
头颈部癌症发病率和吸烟率的趋势进行审查，讨论在这种趋势平行，但如何以及为什么他们可能不会。在美国，烟草控制和教育方面的公共卫生努力成功地减少了吸烟的流行，从而降低了头颈癌的发病率。应继续警惕预防吸烟和鼓励戒烟，并应针对特定的族裔和社会经济群体扩大努力。然而，在口咽癌发病率中观察到了不幸的停滞，这可能反映了这种疾病越来越多地归因于致癌的人乳头瘤病毒，特别是16型（HPV-16）。在可预见的未来，口咽癌发病率的这一趋势可能会持续下去，但随着时间的推移，青少年和年轻成年女性人群接种疫苗的效果应该会降低病毒流行率，并有望降低口咽癌的发病率。为了加速降低人群中HPV-16的流行率，还应考虑对青少年和年轻成年男性进行广泛的疫苗接种。
The trends in head and neck cancer incidence and smoking prevalence are reviewed, discussing where such trends parallel but also how and why they may not. In the U.S., public health efforts at tobacco control and education have successfully reduced the prevalence of cigarette smoking, resulting in a lower incidence of head and neck cancer. Vigilance at preventing tobacco use and encouraging cessation should continue, and expanded efforts should target particular ethnic and socioeconomic groups. However, an unfortunate stagnation has been observed in oropharyngeal cancer incidence and likely reflects a rising attribution of this disease to oncogenic human papillomavirus, in particular type 16 (HPV-16). For the foreseeable future, this trend in oropharyngeal cancer incidence may continue, but with time the effects of vaccination of the adolescent and young adult female population should result in a lower viral prevalence and hopefully a reduced incidence of oropharyngeal cancer. To hasten the reduction of HPV-16 prevalence in the population, widespread vaccination of adolescent and young adult males should also be considered.