The Role of Androgens and Estrogens on Healthy Aging and Longevity
The Role of Androgens and Estrogens on Healthy Aging and Longevity
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DOI：
10.1093/gerona/gls068
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发表时间：
2012-11-01
影响因子：
5.1
通讯作者：
Sheffield-Moore, Melinda
中科院分区：
文献类型：
--
作者：
Horstman, Astrid M.;Dillon, E. Lichar;Sheffield-Moore, Melinda
衰老与男性（男性更年期）和女性（更年期）性激素的丧失有关。在男性中，睾丸激素的减少会引发肌肉质量，骨量和身体功能的下降。在女性中，性激素（如雌二醇）的损失对骨骼的影响已得到很好的阐明，但关于雌二醇的损失是否会对肌肉质量和身体功能产生负面影响的证据有限。然而，多种合成代谢激素的缺乏已被证明可以预测老年人的健康状况和寿命。因此，应考虑是否有针对性的激素替代疗法可以证明有效治疗临床条件，如年龄相关的肌肉减少症，癌症恶病质，和/或急性或慢性疾病。如果在适当的临床人群中谨慎地开始，男性和女性的激素替代疗法可能会预防和逆转肌肉和骨质流失以及功能下降，并可能促进健康的衰老和长寿。
Aging is associated with a loss of sex hormone in both men (andropause) and women (menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone mass, and in physical function. In women, the impact of the loss of sex hormones, such as estradiol, on bone is well elucidated, but evidence is limited on whether the loss of estradiol negatively affects muscle mass and physical function. However, deficiencies in multiple anabolic hormones have been shown to predict health status and longevity in older persons. Thus, consideration should be given as to whether targeted hormone replacement therapies may prove effective at treating clinical conditions, such as age-related sarcopenia, cancer cachexia, and/or acute or chronic illnesses. If initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity.