Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance.
Relationship between body composition and left ventricular geometry using three dimensional cardiovascular magnetic resonance.
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DOI：
10.1186/s12968-016-0251-4
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发表时间：
2016-05-31
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影响因子：
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通讯作者：
O'Regan DP
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文献类型：
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作者：
Corden B;de Marvao A;Dawes TJ;Shi W;Rueckert D;Cook SA;O'Regan DP
虽然肥胖与左心室(LV)质量和体积的改变有关，这对预后有重要意义，但肥胖症的重塑模式大相径庭。我们的目的是利用三维心血管磁共振来确定身体成分和左心室几何形状之间的关系。在一项观察性研究中，1530名没有已知心血管疾病的志愿者(55%女性，平均年龄41.3岁)接受了包括屏气高空间分辨率3D电影在内的调查。使用基于Atlas的分割和配准来创建整个左室壁厚度(WT)和相对壁厚度(RWT)的统计模型。根据年龄、血压、性别、种族和身高调整后的3D回归模型评估生物阻抗性体成分与左心室几何形状的关系，并进行校正以控制误发率。女性LV质量与脂肪质量呈正相关，而男性LV质量与脂肪质量无相关性(LV质量：女性β = 0.11，p <； 0.0001；男性β = −0.01，p = 0.82)。3D模型显示，在男性中，脂肪质量与左心室大部分向心性相对壁厚(β = 0.37，显著面积 = 96%)和脑室中腔(β = −0.22，显著面积 = 91%)的同心性增加密切相关。在女性中，区域性向心性肥厚相关性较弱，基础侧壁与脂肪质量呈负相关(β = −为0.11，显著面积 = 为4.8%)。在没有已知心血管疾病的成年人群中，体脂增加主要与不对称性向心性肥厚有关，与收缩压无关，女性表现出比男性更大的空腔扩张。传统的质量和体积测量低估了人体成分对左心室结构的影响，这是由于重构过程中的解剖差异造成的。本文的在线版本(doi：10.1186/s12968-0160251-4)包含补充材料，可供授权用户使用。
Although obesity is associated with alterations in left ventricular (LV) mass and volume which are of prognostic significance, widely differing patterns of remodelling have been attributed to adiposity. Our aim was to define the relationship between body composition and LV geometry using three-dimensional cardiovascular magnetic resonance. In an observational study 1530 volunteers (55 % female, mean age 41.3 years) without known cardiovascular disease underwent investigation including breath-hold high spatial resolution 3D cines. Atlas-based segmentation and co-registration was used to create a statistical model of wall thickness (WT) and relative wall thickness (RWT) throughout the LV. The relationship between bio-impedence body composition and LV geometry was assessed using 3D regression models adjusted for age, systolic blood pressure (BP), gender, race and height, with correction to control the false discovery rate. LV mass was positively associated with fat mass in women but not in men (LV mass: women β = 0.11, p < 0.0001; men β = −0.01, p = 0.82). The 3D models revealed that in males fat mass was strongly associated with a concentric increase in relative wall thickness (RWT) throughout most of the LV (β = 0.37, significant area = 96 %) and a reduced mid-ventricular cavity (β = −0.22, significant area = 91 %). In women the regional concentric hypertrophic association was weaker, and the basal lateral wall showed an inverse relationship between RWT and fat mass (β = −0.11, significant area = 4.8 %). In an adult population without known cardiovascular disease increasing body fat is predominately associated with asymmetric concentric hypertrophy independent of systolic BP, with women demonstrating greater cavity dilatation than men. Conventional mass and volume measurements underestimate the impact of body composition on LV structure due to anatomic variation in remodelling. The online version of this article (doi:10.1186/s12968-016-0251-4) contains supplementary material, which is available to authorized users.