Morphine modulates monocyte-macrophage conversion phase
Morphine modulates monocyte-macrophage conversion phase
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DOI：
10.1016/j.cellimm.2006.03.004
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发表时间：
2006-01-01
影响因子：
4.3
通讯作者：
Singhal, Pravin C.
中科院分区：
文献类型：
--
作者：
Hatsukari, Ikuske;Hitosugi, Naoko;Singhal, Pravin C.
Monocyte migration and their activation into the macrophage phenotype play a role in the modulation Of tissue injury. We studied the effect of morphine on the monocyte-rnacrophage conversion phase (MMCP). Phorbol 12-myristate 13-acetate (PMA) activated THP-1 cells and promoted their adhesion to the substrate. Morphine inhibited PMA-induced MMCR However. opiate receptor antagonists attenuated this effect of morphine. Interestingly, PMA as well as morphine-stimulated superoxide production by monocytes. Superoxide dismutase (SOD) not only inhibited PMA-mediated MMCP but also attenuated the inhibitory effect of morphine. PMA not only enhanced adhesion of monocytes to a filter but also promoted their migration. These findings suggest that the PMA-induced macrophage phenotype conversion may be accelerating their migration: whereas. morphine may be preventing the migration of monocytes by inhibiting MMCP. (c) 2006 Elsevier Inc. All rights reserved.
