WEIGHT-LOSS RESULTS IN SIGNIFICANT IMPROVEMENT IN PREGNANCY AND OVULATION RATES IN ANOVULATORY OBESE WOMEN
WEIGHT-LOSS RESULTS IN SIGNIFICANT IMPROVEMENT IN PREGNANCY AND OVULATION RATES IN ANOVULATORY OBESE WOMEN
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DOI：
10.1093/oxfordjournals.humrep.a135772
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发表时间：
1995-10-01
影响因子：
6.1
通讯作者：
NORMAN, RJ
中科院分区：
文献类型：
--
作者：
CLARK, AM;LEDGER, W;NORMAN, RJ
肥胖可以影响排卵和怀孕的机会，在这项前瞻性研究中，评估了一项减肥计划，以确定它是否可以帮助不育的超重无排卵妇女建立排卵并帮助实现怀孕，理想情况下，受试者作为自己的历史对照，他们在6个月内接受了与锻炼和饮食有关的每周行为改变计划；未完成6个月的女性作为对照组，研究组女性平均减重6.3公斤，13名受试者中有12名恢复排卵，11名受试者怀孕，其中5名自然受试者，体能、饮食和心理测量都有所改善，空腹胰岛素和睾酮浓度显著下降，而性激素结合球蛋白浓度上升。这些变化在对照组中均未发生。因此，减轻体重，进而改善排卵、妊娠结局、自尊和内分泌参数，是不孕不育和超重女性的首选治疗方案。
Obesity can affect ovulation and the chances of pregnancy, In this prospective study, a weight loss programme was assessed to determine whether it could help infertile overweight anovulatory women to establish ovulation and assist in achieving pregnancy, ideally without further medical intervention, The subjects acted as their own historical controls, They underwent a weekly programme of behavioural change in relation to exercise and diet over 6 months; those who did not complete the 6 months were treated as the comparison group, Women in the study group lost an average of 6.3 kg, with 12 of the 13 subjects resuming ovulation and 11 becoming pregnant, five of these spontaneously, Fitness, diet and psychometric measurements all improved, Fasting insulin and testosterone concentrations dropped significantly, while sex hormone binding globulin concentrations rose. None of these changes occurred in the comparison group. Thus, weight loss with a resultant improvement in ovulation, pregnancy outcome, self-esteem and endocrine parameters is the first therapeutic option for women who are infertile and overweight.