Cell adhesion molecules in Drosophila synapse development and function
Cell adhesion molecules in Drosophila synapse development and function
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DOI：
10.1007/s11427-012-4273-3
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发表时间：
2012-02
期刊：
影响因子：
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通讯作者：
Mingkuan Sun;Wei Xie
中科院分区：
文献类型：
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作者：
Mingkuan Sun;Wei Xie
突触是神经元之间或神经元与其靶细胞之间的高度特化的细胞间结构，其介导细胞-细胞通信。大量的研究结果表明，突触粘附分子在调节突触的复杂性和特异性方面至关重要。而突触粘附特性的破坏可能导致神经发育或神经退行性疾病。在这篇综述中，我们将使用果蝇NMJ作为一个模型系统的神经元能突触讨论的结构和功能的嗜同性和嗜异性的突触粘附分子，特别是最近的研究结果neurexins和neuroligins在果蝇。
Synapse is a highly specialized inter-cellular structure between neurons or between a neuron and its target cell that mediates cell-cell communications. Ample results indicate that synaptic adhesion molecules are critically important in modulating the complexity and specificity of the synapse. And disruption of adhesive properties of synapses may lead to neurodevelopmental or neurodegenerative diseases. In this review, we will use the Drosophila NMJ as a model system for glutamatergic synapses to discuss the structure and function of homophilic and heterophilic synaptic adhesion molecules with special focus on recent findings in neurexins and neuroligins in Drosophila.