Direct Visualization of Parkinson's Disease by In Vivo Human Brain Imaging Using 7.0T Magnetic Resonance Imaging
Direct Visualization of Parkinson's Disease by In Vivo Human Brain Imaging Using 7.0T Magnetic Resonance Imaging
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DOI：
10.1002/mds.23465
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发表时间：
2011-03-01
影响因子：
8.6
通讯作者：
Jeon, Beom S.
中科院分区：
文献类型：
--
作者：
Cho, Zang-Hee;Oh, Se-Hong;Jeon, Beom S.
帕金森病（PD）是一种神经退行性疾病，由黑质（SN）致密部多巴胺能神经元的进行性丧失引起。因此，SN的成像被认为在PD的诊断中具有最大的潜力。在7.0T的磁共振成像（MRI）下，现在可以清晰地描绘SN的形状和边界。我们使用7.0T MRI扫描了8名早期PD患者和2名晚期PD患者，以及9名年龄匹配的对照者，试图直接观察PD患者的SN，并量化PD患者与正常对照者之间SN形状和边界的差异。在正常对照中，SN和大脑小腿之间的边界平滑，从后向前腹侧伸展的“拱形”形状清晰。相比之下，PD患者失去了这些光滑干净的拱形边界。测量相关性分析显示，在PD患者中，存在年龄依赖相关性和明显更强的UPDRS运动评分依赖相关性。这些结果表明，通过使用7.0T MRI，这些可见的和独特的形态学变化似乎可以作为PD的诊断标志。(C) 2011运动障碍学会
Parkinson's disease (PD) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta. Therefore, imaging of the SN has been regarded to hold greatest potential for use in the diagnosis of PD. At the 7.0T magnetic resonance imaging (MRI), it is now possible to delineate clearly the shapes and boundaries of the SN. We scanned eight early and two advanced PD patients, along with nine age-matched control subjects, using a 7.0T MRI in an attempt to directly visualize the SN and quantify the differences in shape and boundaries of SN between PD subjects in comparison with the normal control subjects. In the normal controls, the boundaries between the SN and crus cerebri appear smooth, and clean "arch'' shapes that stretch ventrally from posterior to anterior. In contrast, these smooth and clean arch-like boundaries were lost in PD subjects. The measured correlation analyses show that, in PD patients, there is age-dependent correlation and substantially stronger UPDRS motor score-dependent correlation. These results suggest that, by using 7.0T MRI, it appears possible to use these visible and distinctive changes in morphology as a diagnostic marker of PD. (C) 2011 Movement Disorder Society