Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells:: protective effects of phenolic compounds
Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells:: protective effects of phenolic compounds
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DOI：
10.1016/j.jnutbio.2007.01.010
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发表时间：
2008-02-01
影响因子：
5.6
通讯作者：
Masella, Roberta
中科院分区：
文献类型：
--
作者：
Giovannini, Claudio;Scazzocchio, Beatrice;Masella, Roberta
在本研究中，我们研究了氧化低密度脂蛋白脂组分对Caco-2肠道细胞氧化还原平衡的影响，以及酪醇和原儿茶酸这两种膳食酚类化合物的影响。结果发现，氧化低密度脂蛋白(OxLDL)中的氧化脂质(Lipe)可诱导氧化应激，作用6h后，ROS的过量产生(O-2(-)和H_2O_2的产生分别增加约100%和43%，P
In this study, we investigated the alterations of the redox balance induced by the lipid fraction of oxLDL in Caco-2 intestinal cells, and the effects of tyrosol and protocatechuic acid, two dietary phenolic compounds. We found that oxidized lipids extracted from oxLDL (LipE) induced oxidative stress by determining, 6 h after treatment, ROS overproduction (about a 100% and a 43% increase of O-2(-) and H2O2 production, respectively, P