Celiac Disease and Drug-Based Therapies: Inquiry into Patients Demands
Celiac Disease and Drug-Based Therapies: Inquiry into Patients Demands
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DOI：
10.1159/000441697
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发表时间：
2016-01-01
期刊：
影响因子：
3.2
通讯作者：
Elli, Luca
中科院分区：
文献类型：
--
作者：
Branchi, Federica;Tomba, Carolina;Elli, Luca
背景/目的：医学研究正在寻找无麸质饮食(GFD)治疗乳糜泻的替代药物。我们的目的是评估乳糜泻患者对替代疗法的需求。方法：在2013年意大利腹水患者协会伦巴第部会议期间，成年受试者被邀请填写一份问卷，调查他们对饮食的依从性、生活质量(QOL)以及他们对替代疗法的看法。结果：372例患者(76 m，平均年龄41.7±13.9岁)完成问卷调查。患者报告在开始饮食后健康状况(HS)和生活质量有显著改善(p<；0.001)。88%的患者接受了GFD，但65%的患者报告需要替代疗法。表示需要药物治疗的受试者在GFD的生活质量(p=0.003)和HS(p=0.005)方面的增长较低。替代疗法的首选选择是使用酶(145名受试者)，其次是疫苗(111名受试者)。结论：GFD可为大多数乳糜泻患者所接受。尽管如此，仍有一部分患者表示支持替代药物的开发。(C)2016年S.Karger AG，巴塞尔
Background/Aim: Medical research is looking for alternative drug-based options to the gluten-free diet (GFD) for celiac disease. We aimed at evaluating the need for alternative therapies perceived by celiac patients. Methods: During the 2013 meeting of the Lombardy section of the Italian Celiac Patients Association, adult subjects were invited to fill in a questionnaire investigating their clinical profile in relation to compliance to the diet, quality of life (QOL) as well as their opinion on alternative therapies. Results: Three hundred and seventy two patients (76 m, mean age 41.7 +/- 13.9 years) completed the questionnaire. Patients reported a significant improvement in health status (HS) and QOL after the diet was started (p < 0.001). The GFD was accepted by 88% patients, but the need for alternative therapies was reported by 65%. Subjects expressing the need for a drug-based therapy showed a lower increase in QOL (p = 0.003) and HS (p = 0.005) on GFD. The preferred option for an alternative therapy was the use of enzymes (145 subjects), followed by a vaccine (111 subjects). Conclusion: The GFD is favorably accepted by most celiac patients. Nevertheless, a proportion of patients pronounce themselves in favor of the development of alternative drugs. (C) 2016 S. Karger AG, Basel