Retinoblastoma gene expression in human non-melanoma skin cancer
Retinoblastoma gene expression in human non-melanoma skin cancer
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DOI：
10.1034/j.1600-0560.2003.00004.x
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发表时间：
2003-09-01
影响因子：
1.7
通讯作者：
Wong, YL
中科院分区：
文献类型：
--
作者：
Edwards, MJ;Thomas, RC;Wong, YL
背景：视网膜母细胞瘤和 p53 肿瘤抑制基因的异常表达与更具侵袭性的肿瘤、转移和较低的生存率相关。方法：我们通过免疫组织化学方法评估了一组含有 p53 体细胞突变的非黑色素瘤皮肤癌中 pRB 的表达。结果：在 18 例 (72%) 分化鳞状细胞癌、6 例 (100%) 未分化鳞状细胞癌中检测到核抗 p53 染色。鳞状细胞癌和七种 (28%) 基底细胞癌。 p53 表达与分化鳞状细胞癌的增殖活性之间观察到相关性（P
Background: The aberrant expression of both the retinoblastoma and p53 tumor suppressor genes has been associated with more aggressive tumors, metastasis and lower survival.Methods: We have evaluated immunohistochemically the expression of pRB in a panel of non-melanoma skin cancers containing p53 somatic mutations.Results: Nuclear anti-p53 staining was detected in 18 (72%) differentiated squamous cell carcinomas, six (100%) undifferentiated squamous cell carcinomas and seven (28%) basal cell carcinomas. A correlation was observed between p53 expression and the proliferative activity of differentiated squamous cell carcinomas ( P