Near-Infrared Spectroscopy Reveals Abnormal Hemodynamics in the Left Dorsolateral Prefrontal Cortex of Menopausal Depression Patients.
Near-Infrared Spectroscopy Reveals Abnormal Hemodynamics in the Left Dorsolateral Prefrontal Cortex of Menopausal Depression Patients.
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DOI：
10.1155/2017/1695930
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Liu PZ
中科院分区：
文献类型：
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作者：
Ma XY;Wang YJ;Xu B;Feng K;Sun GX;Zhang XQ;Liu XM;Shen CY;Ren XJ;Sun JJ;Liu PZ
背景/目的。月经期抑郁症（MD）的特征是伴随激素波动的抑郁症状沿着。目的：探讨抑郁症（MDD）与精神障碍（MD）患者的脑功能改变.方法.采用语言流畅性任务（VFT）结合近红外光谱（NIRS）技术，对90例女性抑郁症（MDD）患者、30例抑郁症（MD）患者和30例健康对照者（HC）的前额叶皮质（PFC）氧合血红蛋白（Oxy-Hb）进行回顾性比较。结果我们观察到MD组和MDD组之间左背外侧PFC（DLPFC）中Oxy-Hb改变的显著差异，使用VFT和NIRS（通道18，P = 0.007）。在双侧DLPFC（通道18、27、33、39、41和45; P < 0.05）中，观察到三组之间的Oxy-Hb水平存在显著差异。与HC相比，MD组右侧DLPFC的Oxy-Hb活性较低（通道41; P = 0.048）和左侧DLPFC（通道18、39和45; P < 0.05），MDD组在右侧DLPFC中表现出较低的Oxy-Hb激活（通道27、33和41; P < 0.05）和左侧DLPFC（通道39和45; P < 0.05）。结论左侧DLPFC血流动力学异常可鉴别MD和MDD。
Background/Objective. Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD. Methods. The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS). Results. We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18, P = 0.007) between the MD and MDD groups. A significant difference in Oxy-Hb levels was observed among the three groups in the bilateral DLPFC (channels 18, 27, 33, 39, 41, and 45; P < 0.05). Compared to the HCs, the MD group presented lower Oxy-Hb activation in the right DLPFC (channel 41; P = 0.048) and the left DLPFC (channels 18, 39, and 45; P < 0.05), and the MDD group presented lower Oxy-Hb activation in the right DLPFC (channels 27, 33, and 41; P < 0.05) and the left DLPFC (channels 39 and 45; P < 0.05). Conclusion. Abnormal hemodynamics of the left DLPFC can differentiate MD from MDD by NIRS.