Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors
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DOI：
10.1073/pnas.0511306103
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发表时间：
2006-02-28
影响因子：
11.1
通讯作者：
Huso, DL
中科院分区：
文献类型：
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作者：
Nanda, A;Karim, B;Huso, DL
肿瘤内皮标志物1（Tem 1;内皮素）是在肿瘤间质中表达的基因家族的原型成员。为了评估Tem 1的功能作用，我们通过靶向同源重组破坏了小鼠的Tem 1基因。Tem 1（-/-）小鼠是健康的，它们的伤口愈合是正常的，并且当皮下植入时肿瘤正常生长。网站.然而，将肿瘤移植到没有功能性Tem 1基因的小鼠腹部部位后，肿瘤生长、侵袭性和转移显着减少。这些数据表明间质可以控制肿瘤的侵袭性，并且这种控制随解剖部位而变化。因此，它们对肿瘤侵袭性的潜在机制和评估这一过程的模型具有重要意义。
Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1(-/-) mice were healthy, their wound healing was normal, and tumors grew normally when implanted in s.c. sites. However, there was a striking reduction in tumor growth, invasiveness, and metastasis after transplantation of tumors to abdominal sites in mice without functional Tem1 genes. These data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site. Therefore, they have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.