IODINE-INDUCED THYROTOXICOSIS - ANALYSIS OF 85 CONSECUTIVE CASES
IODINE-INDUCED THYROTOXICOSIS - ANALYSIS OF 85 CONSECUTIVE CASES
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DOI：
10.1111/j.1365-2362.1984.tb01212.x
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发表时间：
1984-01-01
影响因子：
5.5
通讯作者：
SAVOIE, JC
中科院分区：
文献类型：
--
作者：
LEGER, AF;MASSIN, JP;SAVOIE, JC
碘引起的甲状腺毒症记录在85例。80%发生在明显正常的甲状腺;其中60%发生在男性。胺碘酮占碘致甲状腺毒症的50%。诊断时的平均甲状腺激素水平为：FT1 [游离甲状腺素指数]：21.7（正常均值：7.5，任意单位）; T3 [三碘甲状腺原氨酸]：4.53 nmol 1 - 1（正常：2.30 nmol 1 - 1）。平均131I-24-h摄取率为3.5%（法国正常范围为25 - 45%），并被外源性TSH激活（平均27%）。未治疗病例平均6个月内自行治愈。在恢复到甲状腺功能正常之前有一个生物学甲状腺功能减退阶段（平均FT 1：3.7，T3：1.23 nmol 1 - 1，TSH; 9.6 μ U ml-1（正常TSH范围：1 - 7 μ U ml-1））。用X射线荧光法测得甲状腺内碘含量先高后低。甲状腺组织检查显示甲状腺内碘含量高，甲状腺球蛋白碘化程度高。组织学和EM研究报告。泼尼松和在某些情况下丙基硫氧嘧啶被发现是有效的。
I-induced thyrotoxicosis was documented in 85 cases. Eighty per cent occur in apparently normal thyroid glands; 60% among them occur in males. Amiodarone accounted for 50% of I-induced thyrotoxicosis. Mean thyroid hormone levels at diagnosis were: FT1 [free thyroxine index]: 21.7 (normal mean: 7.5, arbitrary units); T3 [triiodothyronine]: 4.53 nmol 1-1 (normal: 2.30 nmol 1-1). Mean 131I- 24-h uptake was 3.5% (normal range in France 25-45%) and was activated by exogenous TSH (mean 27%). The spontaneous cure in nontreated cases were observed within an average 6 mo. A phase of biological hypothyroidism (mean FT1: 3.7, T3: 1.23 nmol 1-1, TSH; 9.6 .mu.U ml-1 (normal TSH range: 1-7 .mu.U ml-1)) preceded the return to euthyroidism. Intrathyroid I content measured by x-ray fluorescence was high, then fell gradually. Thyroid tissue study showed a large quantity of intrathyroid I and the overiodination of thyroglobulin. Histological and EM studies are reported. Prednisone and in some cases propylthiouracil were found to be effective.