Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population.
Genetic variation in WDR1 is associated with gout risk and gout-related metabolic indices in the Han Chinese population.
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DOI：
10.4238/gmr.15027381
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发表时间：
2016-04
期刊：
影响因子：
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通讯作者：
Lijun Liu;Zhang Xy;N. He;K. Liu;Xugang Shi;T. Feng;T. Geng;D. Yuan;L. Kang;Tianbo Jin
中科院分区：
文献类型：
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作者：
Lijun Liu;Zhang Xy;N. He;K. Liu;Xugang Shi;T. Feng;T. Geng;D. Yuan;L. Kang;Tianbo Jin
痛风是影响男性的炎性关节炎的最常见形式，目前的证据表明，遗传因素有助于其进展。由于先前的一项研究发现，WD 40重复蛋白1（WDR 1）与欧洲血统的人群中的痛风，我们试图调查它与这种疾病在中国汉族人群。我们使用Sequenom MassARRAY技术对143例痛风患者和310例对照者的6个WDR 1单核苷酸多态性进行了基因分型。采用SPSS16.0软件进行统计学分析。优势比（OR）和95%置信区间（CI）通过非条件logistic回归计算，并对年龄和性别进行调整。在使用等位基因模型的分析中，我们确定rs3756230（OR = 0.64，95%CI = 0.450-0.911，P = 0.013）和rs 12498927（OR = 1.377，95%CI = 1.037-1.831，P = 0.027）的次要等位基因与痛风风险相关。在共显性模型（OR = 2.22，95%CI = 1.12- 4.40，P = 0.042）和隐性模型（OR = 2.24，95%CI = 1.20-4.17，P = 0.012）下，rs 12498927“A/A”基因型与痛风发病风险增加相关。我们还确定rs 12498927的“A/G”基因型与痛风患者较高的尿素水平显著相关（P = 0.017）。我们的数据揭示了中国汉族人群中WDR 1基因的遗传变异与痛风易感性之间的关联。
Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression. As a previous study identified that WD40 repeat protein 1 (WDR1) is associated with gout in populations of European descent, we sought to investigate its relationship with this disease in the Han Chinese population. We genotyped six WDR1 single nucleotide polymorphisms in 143 gout cases and 310 controls using Sequenom MassARRAY technology. The SPSS 16.0 software was used to perform statistical analyses. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression, with adjustments for age and gender. In an analysis using an allelic model, we identified that the minor alleles of rs3756230 (OR = 0.64, 95%CI = 0.450-0.911, P = 0.013) and rs12498927 (OR = 1.377, 95%CI = 1.037-1.831, P = 0.027) were associated with gout risk. In addition, we found that the "A/A" genotype of rs12498927 was associated with increased risk of gout under codominant (OR = 2.22, 95%CI = 1.12- 4.40, P = 0.042) and recessive models (OR = 2.24, 95%CI = 1.20-4.17, P = 0.012). We also determined the "A/G" genotype of rs12498927 to be significantly associated with higher urea levels in gout patients (P = 0.017). Our data shed new light on the association between genetic variations in the WDR1 gene and gout susceptibility in the Han Chinese population.