A cross talk between codon usage bias in human oncogenes.
A cross talk between codon usage bias in human oncogenes.
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DOI：
10.6026/97320630010256
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发表时间：
2014
期刊：
影响因子：
1.9
通讯作者：
Paul P
中科院分区：
文献类型：
--
作者：
Mazumder TH;Chakraborty S;Paul P
背景：致癌基因是指有可能诱发癌症的基因。密码子使用偏差的程度和起源是生物基因组进化形成力量的重要指标。结果：我们观察到CAI测量的基因表达与任何密码子位点的GC含量之间存在适度的相关性。结果表明，第1、2个密码子位置的GC含量与第3个密码子位置的GC含量呈显著正相关（Spearman’s r= 0.45， P<0.01）。ENC与各基因GC3s值呈显著负相关（r= -0.771， P<0.01）， CAI与ENC呈显著正相关（r=0.644， P<0.01）。结论：突变压力是形成癌基因密码子使用模式的主要决定因素，而不是自然选择，因为突变压力的影响存在于所有密码子位置。结果表明，密码子使用偏差决定了人癌基因的表达水平。高表达癌基因GC含量丰富，密码子使用偏倚程度高。
Background: Oncogenes are the genes that have the potential to induce cancer. The extent and origin of codon usage bias is an important indicator of the forces shaping genome evolution in living organisms. Results: We observed moderate correlations between gene expression as measured by CAI and GC content at any codon site. The findings of our results showed that there is a significant positive correlation (Spearman's r= 0.45, P<0.01) between GC content at first and second codon position with that of third codon position. Further, striking negative correlation (r = -0.771, P < 0.01) between ENC with the GC3s values of each gene and positive correlation (r=0.644, P<0.01) in between CAI and ENC was also observed. Conclusions: The mutation pressure is the major determining factor in shaping the codon usage pattern of oncogenes rather than natural selection since its effects are present at all codon positions. The results revealed that codon usage bias determines the level of oncogene expression in human. Highly expressed oncogenes had rich GC contents with high degree of codon usage bias.