Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system
Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system
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用于难溶性药物制剂的药物纳米晶体及其作为潜在药物递送系统的应用
DOI：
10.1007/s11051-008-9357-4
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发表时间：
2008-05-01
影响因子：
2.5
通讯作者：
Chen, Minghui
中科院分区：
文献类型：
--
作者：
Gao, Lei;Zhang, Dianrui;Chen, Minghui
难溶药物的配制是药学领域普遍存在的难题，尤其是那些难溶于水和有机介质的化合物。使用传统的处方方法很难解决这个问题，所以许多药物在发现的早期就被放弃了。纳米晶是一种新型的无载体胶体给药系统，其粒径在100~1000 nm之间，由于其制备简单，适用性广，被认为是开发难溶药物的一种可行的药物释放策略。本文对药物纳米晶的制备技术进行了综述和比较，并对药物纳米晶的特点进行了讨论。详细介绍了药物纳米晶在各种给药途径中的应用研究。此外，正如后来介绍的那样，纳米晶体可以很容易地放大，这是将输送系统开发为市场产品的先决条件。
Formulation of poorly soluble drugs is a general intractable problem in pharmaceutical field, especially those compounds poorly soluble in both aqueous and organic media. It is difficult to resolve this problem using conventional formulation approaches, so many drugs are abandoned early in discovery. Nanocrystals, a new carrier-free colloidal drug delivery system with a particle size ranging from 100 to 1000 nm, is thought as a viable drug delivery strategy to develop the poorly soluble drugs, because of their simplicity in preparation and general applicability. In this article, the product techniques of the nanocrystals were reviewed and compared, the special features of drug nanocrystals were discussed. The researches on the application of the drug nanocrystals to various administration routes were described in detail. In addition, as introduced later, the nanocrystals could be easily scaled up, which was the prerequisite to the development of a delivery system as a market product.