Age and sex differences in blood pressure responses during hyperpnoea
Age and sex differences in blood pressure responses during hyperpnoea
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呼吸过度期间血压反应的年龄和性别差异
DOI：
10.1113/ep089171
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发表时间：
2021
影响因子：
2.7
通讯作者：
Katayama Keisho
中科院分区：
文献类型：
--
作者：
Shimizu Kaori;Shiozawa Kana;Ishida Koji;Saito Mitsuru;Mizuno Sahiro;Akima Hiroshi;Katayama Keisho
新发现本研究的中心问题是什么？呼吸肌激活增加通过呼吸肌诱导的代谢反射与神经和心血管后果相关。年龄和/或性别是否会影响自愿性正常二氧化碳递增性呼吸过度时的动脉血压反应？主要发现及其重要性是什么？年轻女性在呼吸过度期间血压的升高幅度小于老年女性，而老年男性和老年女性之间没有差异。在年轻女性的钝呼吸肌诱导的代谢反射是正常的，随着年龄的增长，而老化没有这样的效果在museum.AbstractWe假设，老年女性（OF）有更大的动脉血压反应增加呼吸肌的工作与年轻女性（YF）相比，老年男性（OM）和年轻男性（YM）之间不存在这样的差异。为了验证这些假设，在自愿的正常碳酸增量呼吸过度期间，对老年和年轻受试者的心血管反应进行了评价和比较。增量呼吸耐力试验（IRET）如下进行：目标分钟通气量最初设定为最大自主通气量（MVV 12）的30%，每3分钟增加MVV 12的10%。当受试者无法维持MVV 12的目标百分比时，终止试验。连续记录心率和平均动脉压（MAP）。OM（+24.0 ± 14.7 mmHg，平均值±标准差）与YM（+24.3 ± 13.4 mmHg）在IRT期间MAP较基线的增加（ΔMAP）无差异（P= 0.144），但OF（+31.2 ± 11.6 mmHg）大于（P= 0.004）YF（+10.3 ± 5.5 mmHg）。IRET期间OM和OF之间的ΔMAP无显著差异（P= 0.975）。这些结果表明，呼吸肌诱导的代谢反射在YF中是钝化的，但它可以随着年龄的增长而正常化。在男性中，衰老对呼吸肌诱导的代谢反射几乎没有影响。这些结果表明，老年人呼吸肌诱导的代谢反射没有性别差异。
New FindingsWhat is the central question of this study?Increased respiratory muscle activation is associated with neural and cardiovascular consequences via the respiratory muscle‐induced metaboreflex. Does ageing and/or sex influence the arterial blood pressure response during voluntary normocapnic incremental hyperpnoea?What is the main finding and its importance?The increase in blood pressure during hyperpnoea was smaller in younger females than in older females, whereas no difference was found between older males and older females. The blunted respiratory muscle‐induced metaboreflex in younger females is normalized with advancing age, whereas ageing has no such effect in males.AbstractWe hypothesized that older females (OF) have a greater arterial blood pressure response to increased respiratory muscle work compared with younger females (YF) and that no such difference exists between older males (OM) and younger males (YM). To test these hypotheses, cardiovascular responses during voluntary normocapnic incremental hyperpnoea were evaluated and compared between older and younger subjects. An incremental respiratory endurance test (IRET) was performed as follows: target minute ventilation was initially set at 30% of the maximal voluntary ventilation (MVV12) and was increased by 10% of MVV12 every 3 min. The test was terminated when the subject could not maintain the target percentage of MVV12. Heart rate and mean arterial blood pressure (MAP) were recorded continuously. The increase in MAP from baseline (ΔMAP) during the IRET in OM (+24.0 ± 14.7 mmHg, mean ± SD) did not differ (P= 0.144) from that in YM (+24.3 ± 13.4 mmHg), but it was greater (P= 0.004) in OF (+31.2 ± 11.6 mmHg) than in YF (+10.3 ± 5.5 mmHg). No significant difference in ΔMAP during the IRET was observed between OM and OF (P= 0.975). These results suggest that the respiratory muscle‐induced metaboreflex is blunted in YF, but it could be normalized with advancing age. In males, ageing has little effect on the respiratory muscle‐induced metaboreflex. These results show no sex difference in the respiratory muscle‐induced metaboreflex in older adults.