Rotavirus genome replication and morphogenesis: role of the viroplasm.
Rotavirus genome replication and morphogenesis: role of the viroplasm.
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DOI：
10.1007/3-540-30773-7_6
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发表时间：
2006
影响因子：
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通讯作者：
John T. Patton;Lynn S. Silvestri;M. Tortorici;R. V. Carpio;Z. Taraporewala
中科院分区：
文献类型：
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作者：
John T. Patton;Lynn S. Silvestri;M. Tortorici;R. V. Carpio;Z. Taraporewala
轮状病毒属呼肠孤病毒科，为二十面体三层病毒，基因组由11段双链RNA组成。轮状病毒感染细胞的一个特征是形成大的胞质包涵体，称为病毒颗粒。这些动态和高度组织化的结构作为病毒工厂，指导病毒基因组的包装和复制进入早期衣壳组装中间体。中间体迁移到内质网（ER）启动了一个出芽过程，最终在最终的衣壳组装。最近的信息的发展和组织的病毒，其组件的结构和功能，以及相互作用的途径连接RNA合成和衣壳组装提供了新的见解，这些微环境如何服务于接口的病毒复制和形态发生过程。
The rotaviruses, members of the familyReoviridae, are icosahedral triple-layered viruses with genomes consisting of 11 segments of double-stranded (ds)RNA. A characteristic feature of rotavirus-infected cells is the formation of large cytoplasmic inclusion bodies, termed viroplasms. These dynamic and highly organized structures serve as viral factories that direct the packaging and replication of the viral genome into early capsid assembly intermediates. Migration of the intermediates to the endoplasmic reticulum (ER) initiates a budding process that culminates in final capsid assembly. Recent information on the development and organization of viroplasms, the structure and function of its components, and interactive pathways linking RNA synthesis and capsid assembly provide new insight into how these microenvironments serve to interface the replication and morphogenetic processes of the virus.