Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period.
Motor behavior reflects reduced hemispheric asymmetry in the psychosis risk period.
复制标题
运动行为反映了精神病风险期半球不对称性的减少。
DOI：
10.1016/j.schres.2015.10.017
复制
发表时间：
2016
影响因子：
4.5
通讯作者：
Mittal,VijayA
中科院分区：
文献类型：
--
作者：
Dean,DerekJ;Orr,JosephM;Newberry,RaeanaE;Mittal,VijayA
研究背景一系列关于大脑连接、语言优势和运动侧化的研究表明，大脑半球不对称性的降低是精神分裂症的核心特征。然而，很少有共识是否减少的优势是存在于那些在高风险（UHR）为psychiatris.MethodsA共94个证明右手神经阻滞剂免费参与者（38 UHR和56匹配的健康对照）进行了评估，结构化的临床访谈，并完成了创新的手写任务，使用数字平板电脑。使用参与者左右手的运动学变量计算偏侧商数（LQ）。一个子集的样本（26 UHR和29个对照）返回12个月后完成临床访谈，以检查手写偏侧性和精神病风险symptoms.ResultsThe进展之间的关系UHR组表现出下降的右旋性相比，健康对照组。在12个月的随访中，下降的右旋性占8%的方差在UHR group.ConclusionThe目前的结果表明，中断的大脑优势也存在于高风险期和减少的右旋性可能作为一种新的生物标志物的精神病风险的进展。
BackgroundA body of work focusing on brain connectivity, language dominance, and motor laterality research suggests that reduced hemispheric asymmetry is a core feature in schizophrenia. However, there is little consensus about whether reduced dominance is present in those at ultrahigh risk (UHR) for psychosis.MethodsA total of 94 demonstrated right-handed neuroleptic free participants (38 UHR and 56 matched healthy controls) were assessed with structured clinical interviews and completed an innovative handwriting task using a digital tablet computer. A laterality quotient (LQ) was calculated using kinematic variables from the participant's left and right hands. A subset of the sample (26 UHR and 29 controls) returned after 12-months to complete clinical interviews in order to examine relationships between handwriting laterality and progression of psychosis risk symptoms.ResultsThe UHR group showed decreased dextrality compared to healthy controls. At the 12-month follow-up, decreased dextrality accounted for 8% of the variance in worsened positive symptoms within the UHR group.ConclusionThe current results suggest that disrupted cerebral dominance is also present in the ultrahigh risk period and that decreased dextrality may serve as a novel biomarker for the progression of psychosis risk.