"Mistletoe sign": probably a new dermoscopic descriptor for melanoma in situ and melanocytic junctional nevus in the inflammatory stage
"Mistletoe sign": probably a new dermoscopic descriptor for melanoma in situ and melanocytic junctional nevus in the inflammatory stage
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DOI：
10.5114/pdia.2013.38362
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发表时间：
2013-01-01
影响因子：
1.4
通讯作者：
Wydmanski, Jerzy
中科院分区：
文献类型：
--
作者：
Kaminska-Winciorek, Grazyna;Wlaszczuk, Pawel;Wydmanski, Jerzy
原位黑色素瘤 (MIS) 很难诊断，因为它们缺乏完善的皮肤镜描述符。在许多临床病例中，非典型痣和原位黑色素瘤之间没有明确的区分标准。到目前为止，还没有制定出可以清楚区分非典型痣和 MIS 的数字皮肤镜标准。有必要在皮肤镜检查中寻找 MIS 和临床可疑皮肤病变的预测因子。我们介绍了 2 名被诊断患有原位黑色素瘤和处于炎症阶段的交界痣并接受治疗的患者。这包括皮肤镜检查中称为“槲寄生标志”的新形态结构。下面，我们描述了具有“槲寄生征”的患者的皮肤镜图片，以及适当的组织病理学。两例皮肤镜检查显示多个界限清楚的区域，由不均匀、有时伪二分分支结构组成，模仿伪足，这些伪足不是网状的，是由类似于槲寄生的整体网状或同质图案产生的。由于这是此类报告的几篇之一，仍有必要进一步研究和观察。 “槲寄生征”可能是炎症阶段黑素细胞痣和原位黑色素瘤的描述词；然而，还需要进一步研究。
Melanomas in situ (MIS) are difficult to diagnose as they lack well-established, dermoscopic descriptors. In numerous clinical cases, there are no definitive differentiating criteria between atypical nevus and melanoma in situ. So far, no digital dermoscopic criteria have been developed which can clearly distinguish atypical naevi from MIS. It is necessary to search for predictors of MIS and clinically suspected skin lesions in dermoscopy. We present 2 patients diagnosed with and treated for melanoma in situ and junctional nevus in its inflammatory stage. This includes a new morphological structure in dermoscopy known as the "mistletoe sign". Below, we have described dermoscopic pictures, with appropriate histopathology, for patients with the "mistletoe sign". Dermoscopy in two cases revealed multiple, well-circumscribed areas, consisting of non-uniform, sometimes pseudo-dichotomously branched structures, mimicking pseudopods, which were not reticular, arising from overall reticular or homogenous patterns resembling the mistletoe. Due to the fact that this is one of the several reports of its kind, further research and observation are still necessary. The "mistletoe sign" may be a descriptor of the melanocytic nevus in the inflammatory stage and the melanoma in situ; however, further studies are necessary.