Association of eIF3 p170 expression with chemotherapy response of lung cancer and its effects on cisplatin sensitivity in lung carcinoma cells
Association of eIF3 p170 expression with chemotherapy response of lung cancer and its effects on cisplatin sensitivity in lung carcinoma cells
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eIF3 p170表达与肺癌化疗反应的关系及其对肺癌细胞顺铂敏感性的影响
DOI：
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发表时间：
2007
影响因子：
3.9
通讯作者：
Jie Shen, Hai-Tang Xie, Ji-Ye Yin, Hong-Hao Zhou,
中科院分区：
文献类型：
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作者：
Jie Shen, Hai-Tang Xie, Ji-Ye Yin, Hong-Hao Zhou,
AIM: To evaluate the expression of eukaryotic initiation factors 3(eIF3) subunit 170 (eIF3 P170) in lung cancer tissues and its association with chemotherapy response of lung cancer. METHODS: 31 paraffin imbedded slices of lung cancer tissue from fiberscope diagnosis, 20 samples of benign lung tissues from inflammatory pseudotumor and bronchiectasis, and 10 samples of normal lung tissues from surgical operation were collected. The protein expression of eIF3 p170 in lung-cancer tissues, benign lesion tissues, and normal lung tissues were determined by immunohistochemical staining. RESULTS: The positive ratio of eIF3 p170 expression in lung cancer tissues is higher than those in normal and benign tissues, the lung cancer patients with a higher expression level of eIF3 p170 seems to be more sensitive to chemotherapy. Here, we also found that down-regulation of expression of eIF3 p170 could inhibit the growth of human lung adeno-carcinoma cell A549 cells and decrease the sensitivity of A549 to cisplatin. CONCLUSION: Our data suggest that eIF3 p170 may be involved in the pathogenesis of lung cancer and it appears to be associated with chemotherapy response of lung cancer.
