The NR1 N‐Methyl‐d‐Aspartate Subunit and Brain‐derived Neurotrophic Factor in Temporal Lobe Epilepsy Hippocampus: A Comparison of Patients with and without Coexisting Psychiatric Symptoms
The NR1 N‐Methyl‐d‐Aspartate Subunit and Brain‐derived Neurotrophic Factor in Temporal Lobe Epilepsy Hippocampus: A Comparison of Patients with and without Coexisting Psychiatric Symptoms
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DOI：
10.1111/j.1528-1167.2007.01194.x
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发表时间：
2007-12
期刊：
影响因子：
5.6
通讯作者：
C. Toro;J. Hallak;J. S. Dunham;J. Leite;A. Sakamoto;R. Guarnieri;Vivian Fong;J. Deakin
中科院分区：
文献类型：
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作者：
C. Toro;J. Hallak;J. S. Dunham;J. Leite;A. Sakamoto;R. Guarnieri;Vivian Fong;J. Deakin
目的：谷氨酸N-甲基-d-天冬氨酸(NMDA)受体和神经营养因子脑源性神经营养因子参与了精神分裂症和抑郁症的病理生理过程。由于这些精神障碍在颞叶癫痫(TLE)中很常见，比较有无精神症状的TLE患者可能有助于揭示精神病或抑郁的病理生理机制。
Purpose: The glutamate N‐methyl‐d‐aspartate (NMDA) receptor and the neurotrophin brain‐derived neurotrophic factor have been implicated in the pathophysiology of schizophrenia and depression. Since these psychiatric disorders are common in temporal lobe epilepsy (TLE), a comparison of TLE patients with and without coexisting psychiatric symptoms may be useful to unravel pathophysiologic mechanisms for psychosis or depression.