Inductive effects of triiodothyronine or dihydrotestosterone on EGF in the submandibular glands of young, middle-aged, and old C57BL/6NNia female mice.
Inductive effects of triiodothyronine or dihydrotestosterone on EGF in the submandibular glands of young, middle-aged, and old C57BL/6NNia female mice.
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三碘甲状腺原氨酸或二氢睾酮对年轻、中年和老年 C57BL/6NNia 雌性小鼠下颌下腺 EGF 的诱导作用。
DOI：
10.1093/geronj/42.5.491
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Maruyama,S
中科院分区：
文献类型：
--
作者：
Gresik,EW;Maruyama,S
以4、12、24月龄的C57BL/6NNia雌性小鼠为实验对象，研究了年龄增长对下颌骨腺颗粒曲小管（GCT）细胞对甲状腺原氨酸（T3）或二氢睾酮（DHT）的反应性的影响。在未治疗的小鼠中，GCT的绝对体积和EGF免疫染色细胞的频率随着年龄的增长而增加。EGF浓度上升了4倍。t3和DHT在各年龄段均有诱导作用：GCT细胞体积增大，颗粒较多，EGF染色强烈；EGF浓度和gct体积也增加。然而，两种激素的诱导模式随年龄不同而不同。t3处理后，EGF浓度相对于相同年龄对照水平的诱导程度随年龄而下降。相比之下，DHT处理后的EGF诱导水平高于对照水平，在所有三个年龄均相同。雌性小鼠GCT细胞的衰老模式及其对t3或DHT的反应性与先前报道的雄性小鼠不同。
Effects of advancing age on responsiveness to trüodothyronine (T3) or dihydrotestosterone (DHT) by granular convoluted tubule (GCT) cells in submandibular glands were studied in C57BL/6NNia female mice of 4,12, and 24 months of age. In untreated mice, absolute GCT volume and the frequency of cells strongly immunostained for EGF increased with age. Concentrations of EGF rose fourfold. Both T3and DHT had inductive effects at each age: GCT cells were enlarged, contained more granules, and stained very strongly for EGF; EGF concentrations and the volume of GCTs also increased. However, the pattern of induction differed with age for the two hormones. After T3treatment EGF concentration declined with age with respect to the degree of induction over same age control levels. By contrast, after DHT treatment the level of induction of EGF over control levels was the same at all three ages. The pattern of aging of GCT cells and their responsiveness to T3or DHT in female mice differ from that previously reported for males.