Inhibition of ERK/MAPK suppresses avian leukosis virus subgroup A and B replication
Inhibition of ERK/MAPK suppresses avian leukosis virus subgroup A and B replication
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DOI：
10.1016/j.micpath.2016.11.014
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发表时间：
2017-01-01
影响因子：
3.8
通讯作者：
Cao, Weisheng
中科院分区：
文献类型：
--
作者：
Dai, Mantuan;Feng, Min;Cao, Weisheng
We have previously shown that the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway contributes to subgroup J avian leukosis virus (ALV J)replication and tumorigenicity. However, a role for ERK/MAPK signaling in ALV-A and ALV-B replication is unknown. In this study we successfully constructed and recovered a recombinant form of ALV-A strain GD13-1 which showed similarities in growth to the parental wild type virus in vitro. ALV subgroups J, A or B all triggered ERK2 activation in primary CEF cells. ERK/MAPK inhibition markedly suppressed ALV-A and ALV-B replication as shown by extremely low levels of viral transcription and virus protein production. This finding provides evidence that ERK/MAPK signaling responses play important roles in ALV replication and may represent novel drug targets for therapeutic intervention strategies. (C) 2016 Elsevier Ltd. All rights reserved.
