DNA damage and metabolic mechanisms of cancer drug resistance.
DNA damage and metabolic mechanisms of cancer drug resistance.
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DOI：
10.20517/cdr.2021.148
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发表时间：
2022
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癌症耐药性是确保持久治疗效果需要克服的主要障碍之一。虽然在最初的联合疗法、随后的靶向疗法，以及现在拓展到免疫调节药物或代谢靶向化合物方面取得了许多关键进展，但耐药性最终仍然普遍致命。在这篇简短的综述中，我们将讨论用于对抗耐药性的不同策略，从合成致死到肿瘤微环境调节，重点关注肿瘤细胞内及其周围微环境中的DNA损伤反应和肿瘤代谢。通过这种方式，更好地理解可靶向突变以及代谢情况，或许可以设计出更智能的药物来对抗癌症耐药性。
Cancer drug resistance is one of the main barriers to overcome to ensure durable treatment responses. While many pivotal advances have been made in first combination therapies, then targeted therapies, and now broadening out to immunomodulatory drugs or metabolic targeting compounds, drug resistance is still ultimately universally fatal. In this brief review, we will discuss different strategies that have been used to fight drug resistance from synthetic lethality to tumor microenvironment modulation, focusing on the DNA damage response and tumor metabolism both within tumor cells and their surrounding microenvironment. In this way, with a better understanding of both targetable mutations in combination with the metabolism, smarter drugs may be designed to combat cancer drug resistance.