Research reports on treatments for bipolar disorder: preliminary assessment of methodological quality.
Research reports on treatments for bipolar disorder: preliminary assessment of methodological quality.
复制标题
双相情感障碍治疗的研究报告：方法学质量的初步评估。
DOI：
10.1111/j.1600-0447.2005.00575.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Baldessarini,RJ
中科院分区：
文献类型：
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作者：
Soldani,F;Ghaemi,SN;Baldessarini,RJ
目的：评估双相情感障碍（BD）的出版物类型的频率和评估方法学质量的治疗studies.Method：我们分类100随机选择的文章（1998-2002年）从五个精神病学期刊最高的影响力评级，主题领域，并评估方法采用的治疗studies.Results：主题排名：治疗（41%; 37%的药物治疗）>生物学（31%）>精神病理学（14%）=杂项（14%）。 在治疗研究中，只有19%的原始文章是随机的，15%是相对较大的（n≥ 50）但非随机的，65%是小型非随机病例系列或报告，53%依赖于基线-终点对比，没有对照组。 43%的前瞻性研究中患者脱落率≥40%。只有两份报告提供了置信区间，一个包括功率分析，53%包括没有参考研究设计或统计方法。结论：即使在备受推崇的期刊，典型的方法质量的治疗BD最近的报告出乎意料的有限，精神病理学和心理治疗很少研究。
Objective:To assess frequencies of types of publications about bipolar disorder (BD) and evaluate methodological quality of treatment studies.Method:We classified 100 randomly selected articles (1998–2002) from five psychiatric journals with highest impact ratings, by topic areas, and assessed methods employed in treatment studies.Results:Topics ranked: treatment (41%; 37% on pharmacotherapy) > biology (31%) > psychopathology (14%) = miscellaneous (14%). Of treatment studies, only 19% of original articles were randomized, 15% were relatively large (n≥ 50) but non‐randomized, 65% were small non‐randomized, case‐series or ‐reports, and 53% relied on baseline‐to‐endpoint contrasts without a control group. Patient dropout rates were ≥40% in 43% of prospective studies. Only two reports provided confidence intervals; one included a power analysis, and 53% included no references on study design or statistical methods.Conclusion:Even in highly respected journals, the typical methodological quality of recent reports on therapeutics for BD was unexpectedly limited, and psychopathology and psychotherapies were little studied.