Multiple roles of arginine/serine-rich splicing factors in RNA processing
Multiple roles of arginine/serine-rich splicing factors in RNA processing
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DOI：
10.1042/bst0330443
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发表时间：
2005-06-01
影响因子：
3.9
通讯作者：
C치ceres, JF
中科院分区：
文献类型：
--
作者：
Sanford, JR;Ellis, J;C치ceres, JF
SR蛋白(富含丝氨酸和精氨酸的蛋白质)是一个进化上保守的家族，由必需的前mRNA剪接因子组成。自从它们被发现和初步鉴定以来，SIR蛋白在前mRNA剪接和随后的转录后基因表达步骤中的作用已经显著扩大。目前的假说表明，SR蛋白是多功能的适配器分子，可能耦合不同的RNA代谢步骤。在本研究中，我们将概述SR蛋白在转录后基因表达的不同步骤中的作用。
SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SIR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly. The current hypotheses suggest that SR proteins are multifunctional adaptor molecules that may couple distinct steps of RNA metabolism. in the present study, we will provide an overview of the roles of SR proteins in different steps of post-transcriptional gene expression.