Progesterone-Regulated Endometrial Factors Controlling Implantation.
Progesterone-Regulated Endometrial Factors Controlling Implantation.
复制标题
DOI：
10.1111/aji.12473
复制
发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Bagchi MK
中科院分区：
文献类型：
--
作者：
Bhurke AS;Bagchi IC;Bagchi MK
孕激素（P）通过孕激素受体（PR）亚型PR-A和PR-B发挥作用，对妊娠早期子宫功能产生深远影响。近年来，染色质免疫沉淀测序结合基于微阵列的基因表达谱分析显示，PR亚型控制一个相当大的顺式组和转录组在人类和小鼠子宫内膜分化。基因工程小鼠模型已经建立了几个PR调节基因，如Ihh，Bmp 2，Hoxa 10和Hand 2，是植入和蜕膜化所必需的。PR-A和PR-B还与其他转录因子如FOS、JUN、C/EBPβ和STAT 3协作，以调节许多靶基因的表达，这些靶基因协同作用以适当地控制子宫上皮增殖、基质分化、血管生成和局部免疫应答，从而使子宫“接受”并允许胚胎植入。这篇综述文章强调了最近的工作，描述了关键的PR调节途径，管理关键的子宫功能，在建立怀孕。
The steroid hormone progesterone (P), acting via the progesterone receptor (PR) isoforms, PR-A and PR-B, exerts a profound influence on uterine functions during early gestation. In recent years, chromatin immunoprecipitation-sequencing in combination with microarray-based gene expression profiling analyses have revealed that the PR isoforms control a substantially large cistrome and transcriptome during endometrial differentiation in the human and the mouse. Genetically engineered mouse models have established that several PR-regulated genes, such as Ihh, Bmp2, Hoxa10, and Hand2, are essential for implantation and decidualization. PR-A and PR-B also collaborate with other transcription factors, such as FOS, JUN, C/EBPβ and STAT3, to regulate the expression of many target genes that function in concert to properly control uterine epithelial proliferation, stromal differentiation, angiogenesis, and local immune response to render the uterus ‘receptive’ and allow embryo implantation. This review article highlights recent work describing the key PR-regulated pathways that govern critical uterine functions during establishment of pregnancy.