Molecular Mechanisms of Liver Cancer
Molecular Mechanisms of Liver Cancer
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DOI：
10.2174/187152011796011073
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发表时间：
2011-07-01
影响因子：
2.8
通讯作者：
Huang, Wendong
中科院分区：
文献类型：
--
作者：
Pan, Hongming;Fu, Xianghui;Huang, Wendong
肝癌，特别是肝细胞癌（HCC），是世界范围内最致命的癌症之一，并且HCC的发病率在美国和其他发达国家迅速增加。流行病学研究已经确定了HCC的主要风险因素，包括感染B和C型肝炎病毒（HBV和HCV），暴露于某些化学物质，大量饮酒，以及代谢性疾病，如肥胖和糖尿病，这些疾病在美国迅速增加。虽然肝癌发生的病因学相对明确，但导致癌症发展的确切机制和途径仍不清楚。慢性肝损伤，随后的炎症和不规则的肝再生已被认为是肝癌发生的重要步骤。因此，识别保护肝脏免受损伤和炎症的关键因素可以为HCC的发展提供有价值的见解。本文就近年来肝癌的研究进展作一综述，重点介绍炎症、肝修复和肝癌之间的新的分子联系。
Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the most deadly cancers worldwide, and the incidence of HCC is increasing rapidly in the United States and other developed countries. Epidemiological studies have identified major risk factors for HCC, including infection with hepatitis B and C virus (HBV and HCV), exposure to certain chemicals, high intake of alcohol, as well as metabolic diseases such as obesity and diabetes that are rapidly rising in the US. Although the etiologies for liver carcinogenesis are relatively well defined, the exact mechanism and pathways leading to cancer development are still unclear. Chronic liver injury, followed by inflammation and irregular liver regeneration has been suggested as an important step in hepatocarcinogenesis. Therefore, the identification of key factors that protect the liver from injury and inflammation could provide valuable insight into the development of HCC. In this review, we will summarize the recent findings in HCC studies, mainly focusing on the new molecular link among inflammation, liver repair and HCC.