INFLUENCE OF STZ-INDUCED DIABETES ON ZERO-STRESS STATES OF RAT PULMONARY AND SYSTEMIC ARTERIES
INFLUENCE OF STZ-INDUCED DIABETES ON ZERO-STRESS STATES OF RAT PULMONARY AND SYSTEMIC ARTERIES
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DOI：
10.2337/diabetes.41.2.136
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发表时间：
1992-02-01
期刊：
影响因子：
7.7
通讯作者：
FUNG, YC
中科院分区：
文献类型：
--
作者：
LIU, SQ;FUNG, YC
测定了22只非糖尿病大鼠和29只链脲佐菌素(STZ)诱导的糖尿病大鼠的主肺动脉、主动脉和全身小动脉的零应力状态。每个血管的零应力状态是通过将血管横向切割成一系列短环，然后径向切割每个环，从而使环弹开成一个扇形来获得的。每个扇区都可以通过其开放角度来表征。开放角度具有较强的区域依存性。在大鼠动脉的某些区域，开放角度可达360度。大鼠静脉注射75 mg/kg体重后5、10、20、30、40天。STZ.在糖尿病的发展过程中，开口角总体上增加，并在大约30天内达到平台期。根据位置的不同，开口角的最大变化范围为18-105度。糖尿病对肺动脉和体动脉的影响一样大。糖尿病发生过程中开口角的变化过程与血糖、血压的变化不同。在糖尿病发生过程中，颈动脉、髂外动脉和肺动脉的血压没有明显变化。为了阐明张开角的生理意义，我们测量了动态平衡状态下血管壁的周向应变和无负荷状态下的残余应变，这两种应变都是指零应力状态。我们计算了相应的管壁应力。糖尿病使血管壁的周向应力大大增加，若忽略张开角将产生较大的误差。
Zero-stress states of the main pulmonary arteries and aorta and small systemic arteries were determined in 22 nondiabetic and 29 streptozocin (STZ)-induced diabetic rats. The zero-stress state of each vessel was obtained by cutting the vessel transversely into a series of short rings, then cutting each ring radially, which caused the ring to spring open into a sector. Each sector can be characterized by its opening angle. The opening angle has strong regional dependence. In some regions of rat arteries, the opening angle can be > 360-degrees. Rats were studied 5, 10, 20, 30, and 40 days after an injection of 75 mg/kg body wt i.v. STZ. During diabetes development, the opening angles in general increased and reached a plateau in approximately 30 days. The maximum change of opening angle over normal lies in the range of 18-105-degrees, depending on location. The pulmonary arteries were affected by diabetes as much as the systemic arteries. The course of change of the opening angle during diabetogenesis was different from those of the serum glucose level and blood pressure. Blood pressure in carotid, external iliac, and pulmonary arteries did not change significantly in diabetogenesis. To clarify the physiological meaning of the opening angle, we measured the circumferential strain in the blood vessel wall in homeostatic condition and the residual strain at the no-load state, with both strains referred to the zero-stress state. We calculated the corresponding stresses in the vessel wall. The circumferential stress in the vessel wall was greatly increased by diabetes; great errors will result if the opening angle is ignored.