Biofidelic white matter heterogeneity decreases computational model predictions of white matter strains during rapid head rotations.
Biofidelic white matter heterogeneity decreases computational model predictions of white matter strains during rapid head rotations.
复制标题
生物逼真的白质异质性降低了快速头部旋转期间白质应变的计算模型预测。
DOI：
10.1080/10255842.2016.1176153
复制
发表时间：
2016
影响因子：
1.6
通讯作者：
Margulies,SusanS
中科院分区：
文献类型：
--
作者：
Maltese,MatthewR;Margulies,SusanS
有限元（FE）脑模型越来越多地用作开发减轻创伤性脑损伤技术的设计工具。我们从2个月大的青春期前小猪大脑的CT和MRI扫描中开发了一个超高清FE大脑模型（> 400万个元素），并模拟了快速的头部旋转。在丘脑，冠状辐射，胼胝体，大脑皮层灰质，脑干和小脑的应变分布进行了评估，以确定采用均匀的脑模量，或不同的实验得出的灰色和白色物质的属性表示，其中一些白色物质区域是僵硬和其他较不僵硬的灰质的影响。我们发现，本构异质性显着降低白色物质变形在所有地区相比，均匀的属性，并应纳入有限元模型损伤预测。
The finite element (FE) brain model is used increasingly as a design tool for developing technology to mitigate traumatic brain injury. We developed an ultra high-definition FE brain model (>4 million elements) from CT and MRI scans of a 2-month-old pre-adolescent piglet brain, and simulated rapid head rotations. Strain distributions in the thalamus, coronal radiata, corpus callosum, cerebral cortex gray matter, brainstem and cerebellum were evaluated to determine the influence of employing homogeneous brain moduli, or distinct experimentally derived gray and white matter property representations, where some white matter regions are stiffer and others less stiff than gray matter. We find that constitutive heterogeneity significantly lowers white matter deformations in all regions compared with homogeneous properties, and should be incorporated in FE model injury prediction.