THE REVERSAL OF REJECTION IN HUMAN RENAL HOMOGRAFTS WITH SUBSEQUENT DEVELOPMENT OF HOMOGRAFT TOLERANCE.
THE REVERSAL OF REJECTION IN HUMAN RENAL HOMOGRAFTS WITH SUBSEQUENT DEVELOPMENT OF HOMOGRAFT TOLERANCE.
复制标题
人肾同种移植物排斥反应的逆转以及随后同种移植物耐受性的发展。
DOI：
--
复制
发表时间：
1963
期刊：
影响因子：
--
通讯作者：
W. Waddell
中科院分区：
文献类型：
--
作者：
T. Starzl;T. Marchioro;W. Waddell
由于同种肾移植术后的高失败率，人们对移植肾的长期功能持悲观态度。一般认为，导致排斥反应的免疫学过程是如此强大和持久，以至于使用任何目前可用的抗排斥治疗方法都不能预期持续的成功。
最近护理同种异体肾移植患者的个人经验改变了我们对这类患者管理的许多先入为主的观念。它导致了这样的信念，即拒绝过程几乎永远无法完全阻止，但其影响可以以高度的规律性和完整性逆转。此外，成功治疗排斥危机的患者的后续行为表明，早期出现了某种程度的宿主-移植物适应，因为强烈的继发性排斥现象只发生过一次。
Because of the high failure rate after renal homotransplantation, there has been an air of pessimism concerning the possibility of long term function of the grafted kidney. The immunologic processes subserving rejection are generally thought to be so powerful and persevering that consistent success cannot be expected with the use of any of the currently available methods of antirejection therapy.
Recent personal experience in caring for patients with renal homografts has resulted in alterations in many of our preconceived notions concerning the management of such patients. It has led to the beliefs that the rejection process can almost never be entirely prevented, but that its effects can be reversed with a high degree of regularity and completeness. Furthermore, the subsequent behavior of patients who have been brought through a successfully treated rejection crisis suggests the early development of some degree of host-graft adaptation, since the phenomenon of vigorous secondary rejection has been encountered only once.