Rats with lesions of the hippocampus are impaired on the delayed nonmatching-to-sample task
Rats with lesions of the hippocampus are impaired on the delayed nonmatching-to-sample task
复制标题
DOI：
10.1002/hipo.1035
复制
发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Squire, LR
中科院分区：
文献类型：
--
作者：
Clark, RE;West, AN;Squire, LR
采用4 s的短暂延迟，对具有鹅膏蕈氨酸海马损伤（H-IBO）的大鼠进行试验独特的延迟非匹配样本任务（DNMS）训练。H-IBO组学习不匹配规则的速度与对照组动物一样快。然而，DNMS任务的性能受损时，样品和选择阶段之间的延迟增加到1或2分钟。使用4秒延迟（探针）试验表明，H-IBO动物保留的nonmatching到样品的规则在整个测试。在第二个实验中，使用相同的大鼠组，在1分钟的延迟延长训练并没有改善H-IBO病变产生的赤字。大鼠海马损伤后识别记忆受损的发现与人类和猴子的发现一致。几个方法论问题被认为是复杂的早期研究的认知记忆在大鼠海马损伤后的解释。人类、猴子和啮齿类动物的识别记忆能力被作为一个简单的例子来讨论，这是一个依赖于大脑皮层的（陈述性）记忆。海马2001; 11：176-186.出版于2001年Wiley-Liss，Inc.（匕首）。
Rats with ibotenic acid lesions of the hippocampus (H-IBO) were trained on the trial-unique delayed nonmatching-to-sample task (DNMS) using a short delay of 4 s. The H-IBO group learned the nonmatching rule as quickly as control animals. However, performance was impaired on the DNMS task when the delay between the sample and choice phase was increased to 1 or 2 min. The use of 4-s delay (probe) trials indicated that the H-IBO animals retained the nonmatching-to-sample rule throughout testing. In a second experiment, using the same groups of rats, extended training at the 1-min delay did not ameliorate the deficit produced by H-IBO lesions. The finding of impaired recognition memory in rats after hippocampal lesions is consistent with findings from humans and monkeys. Several methodological issues are considered that have complicated the interpretation of earlier studies of recognition memory in rats following hippocampal lesions. The capacity for recognition memory in humans, monkeys, and rodents is discussed as a straightforward example of hippocampus-dependent (declarative) memory. Hippocampus 2001; 11:176-186. Published 2001 Wiley-Liss, Inc.(dagger).