The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer.
The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer.
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DOI：
10.1038/sj.bjc.6602248
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发表时间：
2004-12-13
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
循环C-反应蛋白浓度与潜在细胞因子和受体介导物的关系（白细胞介素-6，白血病抑制因子（LIF），睫状神经营养因子（CNTF），可溶性IL-6受体，可溶性gp 130，可溶性TNF受体，白细胞介素-1受体拮抗剂和白细胞介素-8（IL-8）在健康受试者（n=11）和非白细胞介素-1受体拮抗剂患者中进行了检测。小细胞肺癌（n=50）。白血病抑制因子和CNTF在所有对照组和患者中均低于检测限。C反应蛋白、白细胞介素6、可溶性糖蛋白130、可溶性肿瘤坏死因子受体、白细胞介素1受体拮抗剂和白细胞介素8浓度在癌症患者中显著升高（P <0.001）。C-反应蛋白水平升高的癌症患者血清中IL-6和IL-1受体拮抗剂水平升高（P<0.01和P<0.05）。在回归分析中，只有IL-6与C-反应蛋白独立相关（r=0.616，P<0.001）。白细胞介素-6是非小细胞肺癌患者C反应蛋白浓度升高的重要独立介质。
The relationship between circulating C-reactive protein concentrations and potential cytokine and receptor mediators (interleukin-6, leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), soluble IL-6 receptor, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and interleukin-8 (IL-8)) of this acute phase protein were examined in healthy subjects (n=11) and patients with non-small-cell lung cancer (n=50). Leukaemia inhibitory factor and CNTF were below detection limits in all controls and patients. C-reactive protein, interleukin-6, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and IL-8 concentrations were significantly elevated in cancer patients (P⩽0.001). Cancer patients with elevated C-reactive protein concentrations had greater concentrations of interleukin-6 (P<0.01) and interleukin-1 receptor antagonist (P<0.05). On regression analysis only interleukin-6 was independently associated with C-reactive protein (r=0.616, P<0.001). Interleukin-6 is an important independent mediator of elevated C-reactive protein concentrations in patients with non-small-cell lung cancer.
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