Proteins produced by Streptococcus species in the lower respiratory tract can modify antiviral responses against influenza virus in respiratory epithelial cells
Proteins produced by Streptococcus species in the lower respiratory tract can modify antiviral responses against influenza virus in respiratory epithelial cells
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DOI：
10.1016/j.micinf.2020.09.010
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发表时间：
2021-02-09
影响因子：
5.8
通讯作者：
Shime, Nobuaki
中科院分区：
文献类型：
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作者：
Nishioka, Keisuke;Kyo, Michihito;Shime, Nobuaki
季节性流感在温带国家的冬季传播。急性呼吸窘迫综合征是一种严重的呼吸系统疾病。我们已经在综合征患者中确定了一种独特的肺部微生物群模式。在这项研究中，我们假设独特的微生物群也与原发性流感病毒性肺炎有关。从患者中检测到的口腔链球菌和缓症链球菌的细菌培养上清液显著增加了肺上皮细胞中的病毒复制（最大增加10倍）。我们的研究结果表明，肺环境微生物群显着参与病毒复制。(C)2020年巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Seasonal influenza spreads during winter in temperate countries. Primary viral pneumoniae resulting from aggravation triggers acute respiratory distress syndrome, which is a serious respiratory disorder. We have identified a unique pattern of lung microbiota in patients with the syndrome. In this study, we hypothesized that the unique microbiota was also associated with primary influenza viral pneumoniae. Bacterial culture supernatants of Streptococcus oralis and Streptococcus mitis detected from the patients significantly increased viral replication (maximum 10-fold increase) in lung epithelial cells. Our results suggest that the lung environment microbiota is significantly involved in viral replication. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.