Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems.
Critical Role of Zinc as Either an Antioxidant or a Prooxidant in Cellular Systems.
复制标题
DOI：
10.1155/2018/9156285
复制
发表时间：
2018
影响因子：
--
通讯作者：
Lee SR
中科院分区：
文献类型：
--
作者：
Lee SR
锌被认为是人类健康所必需的一种痕量金属；它的缺乏与神经和免疫系统缺陷密切相关。虽然锌是一种氧化还原惰性金属，但它通过铜/锌超氧化物歧化酶的催化作用、稳定膜结构、保护蛋白质的巯基和上调金属硫蛋白的表达来发挥抗氧化剂的作用，金属硫蛋白既具有与金属结合的能力，又具有抗氧化功能。此外，锌还能抑制原本会加剧氧化应激的抗炎反应。锌的作用并不简单，因为它在生物系统中扮演着许多角色。已有研究表明，锌缺乏和锌过量都会引起细胞氧化应激。为了深入了解锌作为抗氧化剂或促氧化剂的双重作用，以及每种作用发生的条件，综述了锌缺乏和锌超载时发生的氧化应激以及细胞内游离锌的调节。此外，锌在线粒体动态平衡中的调节作用及其对氧化应激的影响也被简要讨论。
Zinc is recognized as an essential trace metal required for human health; its deficiency is strongly associated with neuronal and immune system defects. Although zinc is a redox-inert metal, it functions as an antioxidant through the catalytic action of copper/zinc-superoxide dismutase, stabilization of membrane structure, protection of the protein sulfhydryl groups, and upregulation of the expression of metallothionein, which possesses a metal-binding capacity and also exhibits antioxidant functions. In addition, zinc suppresses anti-inflammatory responses that would otherwise augment oxidative stress. The actions of zinc are not straightforward owing to its numerous roles in biological systems. It has been shown that zinc deficiency and zinc excess cause cellular oxidative stress. To gain insights into the dual action of zinc, as either an antioxidant or a prooxidant, and the conditions under which each role is performed, the oxidative stresses that occur in zinc deficiency and zinc overload in conjunction with the intracellular regulation of free zinc are summarized. Additionally, the regulatory role of zinc in mitochondrial homeostasis and its impact on oxidative stress are briefly addressed.
登录
查看更多内容
影响因子：
6.1
作者：
CHVAPIL, M
通讯作者：
CHVAPIL, M
影响因子：
4.4
作者：
Dineley, KE;Richards, LL;Reynolds, IJ
通讯作者：
Reynolds, IJ
影响因子：
2.6
作者：
BROWN, JJL
通讯作者：
BROWN, JJL
影响因子：
16.2
作者：
Bossy-Wetzel, E;Talantova, MV;Lipton, SA
通讯作者：
Lipton, SA
影响因子：
4.8
作者：
Brown, AM;Kristal, BS;Cooper, AJL
通讯作者：
Cooper, AJL