Visual Field Change and 24-Hour IOP-Related Profile with a Contact Lens Sensor in Treated Glaucoma Patients
Visual Field Change and 24-Hour IOP-Related Profile with a Contact Lens Sensor in Treated Glaucoma Patients
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DOI：
10.1016/j.ophtha.2015.11.020
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发表时间：
2016-04-01
期刊：
影响因子：
13.7
通讯作者：
Ritch, Robert
中科院分区：
文献类型：
--
作者：
De Moraes, Carlos Gustavo;Jasien, Jessica V.;Ritch, Robert
目的：为了验证接触式透镜传感器（CLS）24小时记录的眼内压（IOP）相关测量值与治疗后青光眼患者视野进展率相关的假设。设计：前瞻性横断面研究。参与者：40名治疗后青光眼患者，进行8次或更多24-2视野测试。方法：使用CLS进行24小时记录，提供IOP相关测量。主要结果测量：CLS记录前和记录时的视野平均偏差（MD）变化率和CLS参数，即大峰数、平均峰比、清醒-睡眠斜率，结果：当比较所有患者CLS记录前和记录时的MD变化率时，开始时的平均斜率比结束时快-0.05 dB/年（P = 0.087），表明CLS记录时的进展减速。患者清醒时的长峰数量和平均峰比是更快进展的最佳预测因子。CLS参数的组合提供了更好的措施比Goldmann IOP参数（平均值，峰值和波动）在同一时期的拟合优度。结论：与CLS 24小时记录获得的眼内压相关参数与治疗后青光眼眼的视野进展率相关。该技术可能有助于检测接受治疗时青光眼进展风险较高的眼睛。(C)2016年美国眼科学会。
Purpose: To test the hypothesis that a 24-hour recording of intraocular pressure (IOP)-related measurements derived from a contact lens sensor (CLS) correlates to the rate of visual field progression in treated glaucomatous eyes.Design: Prospective, cross-sectional study.Participants: Forty treated glaucomatous patients with 8 or more 24-2 visual field tests.Methods: Twenty-fourehour recording with a CLS that provides IOP-related measurements.Main Outcome Measures: Rates of visual field mean deviation (MD) change before and at the time of CLS recording and CLS parameters, namely number of large peaks, mean peak ratio, wake-to-sleep slope, amplitude and area under the cosine curve, and variability from the mean.Results: When comparing the rate of MD change before and at the time of CLS recording of all patients, the average slope was -0.05 dB/year faster in the beginning compared with the end (P = 0.087), suggesting a deceleration of progression by the time of CLS recording. The number of long peaks and the mean peak ratio when patients were awake were the best predictors of faster progression. The combination of CLS parameters provided better measures of goodness of fit than Goldmann IOP parameters (mean, peak, and fluctuation) in the same period.Conclusions: Intraocular pressure-related parameters obtained with 24-hour recording with a CLS were associated with the rate of visual field progression in treated glaucomatous eyes. This technology may be useful in detecting eyes at higher risk of glaucoma progression while receiving treatment. (C) 2016 by the American Academy of Ophthalmology.