Carbamoyl Functionalized Bent para -Phenylenes via an Unexpected Reaction of the Burgess Reagent with α-Ketols
Carbamoyl Functionalized Bent para -Phenylenes via an Unexpected Reaction of the Burgess Reagent with α-Ketols
复制标题
通过 Burgess 试剂与 α-酮醇的意外反应生成氨基甲酰基官能化弯曲对亚苯基
DOI：
10.1021/acs.joc.0c02979
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Merner, Bradley L.
中科院分区：
文献类型：
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作者：
Jackson, Sydney N.;Caskey, Andrew L.;Narayanan, Natasha K.;Merner, Bradley L.
尝试使用 Burgess 试剂对大环 α-酮醇进行脱水，意外地合成了氨基甲酰化的苯对亚苯基单元。与无环类似物的相同反应提供了预期的脱水产物，表明反应性的变化是构象控制的，并且是伯吉斯试剂的双功能性质的结果。
The attempted dehydration of macrocyclic α-ketols with the Burgess reagent has resulted in the unexpected synthesis of carbamoylated, bentpara-phenylene units. The same reaction with an acyclic analogue affords the intended dehydration product, indicating that the change in reactivity is conformationally controlled and a result of the bifunctional nature of the Burgess reagent.