Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells.
Mechanisms of organelle division and inheritance and their implications regarding the origin of eukaryotic cells.
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DOI：
10.2183/pjab.86.455
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kuroiwa T
中科院分区：
文献类型：
--
作者：
Kuroiwa T
线粒体和质体有自己的DNA，被视为内共生原核生物的后代。细胞器 DNA 在体内并不是裸露的，而是与碱性蛋白质结合形成 DNA-蛋白质复合物（称为细胞器核）。细胞器核的概念为解释细胞器的起源、分裂和遗传提供了新的方法。细胞器核分裂后，使用细胞器分裂环（机器）进行细胞器分裂。细胞器分裂机制是细菌来源的 FtsZ（丝状温度敏感 Z）环和真核机械化学动力环的嵌合体。由此可见，细胞器分裂机制蕴藏着解决细胞器（真核生物）起源的一把钥匙。细胞器的母系遗传是在有性生殖过程中发展起来的，也可能与细胞器的起源密切相关。本综述的目的是描述用于揭示细胞器分裂机制动态的策略，以及分裂机制和母系遗传在真核生物起源和进化中的重要性。
Mitochondria and plastids have their own DNAs and are regarded as descendants of endosymbiotic prokaryotes. Organellar DNAs are not naked in vivo but are associated with basic proteins to form DNA-protein complexes (called organelle nuclei). The concept of organelle nuclei provides a new approach to explain the origin, division, and inheritance of organelles. Organelles divide using organelle division rings (machineries) after organelle-nuclear division. Organelle division machineries are a chimera of the FtsZ (filamentous temperature sensitive Z) ring of bacterial origin and the eukaryotic mechanochemical dynamin ring. Thus, organelle division machineries contain a key to solve the origin of organelles (eukaryotes). The maternal inheritance of organelles developed during sexual reproduction and it is also probably intimately related to the origin of organelles. The aims of this review are to describe the strategies used to reveal the dynamics of organelle division machineries, and the significance of the division machineries and maternal inheritance in the origin and evolution of eukaryotes.
DOI：
10.1083/jcb.63.1.299
发表时间：
1974-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kuroiwa T
通讯作者：
Kuroiwa T