Medication, Surgery, and Physiotherapy Among Patients With the Hypermobility Type of Ehlers-Danlos Syndrome
Medication, Surgery, and Physiotherapy Among Patients With the Hypermobility Type of Ehlers-Danlos Syndrome
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DOI：
10.1016/j.apmr.2011.01.016
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发表时间：
2011-07-01
影响因子：
4.3
通讯作者：
Calders, Patrick
中科院分区：
文献类型：
--
作者：
Rombaut, Lies;Malfait, Fransiska;Calders, Patrick
Rombaut L, Malfait F, De Wandele I, Cools A, Thijs Y, De Paepe A, Calders P.多动型ehers - danlos综合征患者的药物、手术和物理治疗。中华医学杂志（英文版）；2011;42(2):1106- 1112。目的：描述药物使用、手术和物理治疗，并检查这些治疗方式对多动型ehers - danlos综合征（EDS-HT）患者功能损害和投诉数量的影响。设计：横断面研究。单位：物理康复医学科和医学遗传学中心。受试者：EDS-HT患者（N=79； 8男，71女）被招募参加本研究。干预措施：不适用。主要结果测量：患者填写关于投诉类型、药物使用、手术、物理治疗和治疗结果的问卷。日常生活中的功能损害通过疾病影响概况来测量。用视觉模拟量表评估疼痛严重程度。结果：患者报告了大量的主诉，相当多的严重疼痛，以及疾病对日常功能的临床显著影响。用药最多（92.4%），以镇痛药为主。56例（70.9%）患者接受了手术，主要包括四肢和腹部的干预。41名患者（51.9%）目前参加了物理治疗项目，主要包括神经肌肉锻炼、按摩和电疗。服用大量镇痛药的患者、看过物理治疗师的患者或接受过手术的患者在日常生活中功能障碍较高。只有33.9%的手术患者和63.4%的物理治疗患者报告了积极的结果。结论：EDS-HT患者有许多主诉和功能受损状态，这强烈决定了他们的高治疗消耗率。手术和物理治疗的结果在很大程度上是令人失望的，这表明了对循证治疗的强烈需求。
Rombaut L, Malfait F, De Wandele I, Cools A, Thijs Y, De Paepe A, Calders P. Medication, surgery, and physiotherapy among patients with the hypermobility type of Ehlers-Danlos syndrome. Arch Phys Med Rehabil 2011;92:1106-12.Objectives: To describe medication use, surgery, and physiotherapy, and to examine the effect of these treatment modalities on functional impairment and amount of complaints among patients with the hypermobility type of Ehlers-Danlos syndrome (EDS-HT).Design: Cross-sectional study.Setting: Physical and rehabilitation medicine department and center for medical genetics.Participants: Patients with EDS-HT (N=79; 8 men, 71 women) were recruited for this study.Interventions: Not applicable.Main Outcome Measures: Patients filled out questionnaires regarding type of complaints, medication use, surgery, physiotherapy, and outcome of treatment. Functional impairment in daily life was measured by the Sickness Impact Profile. Pain severity was assessed with visual analog scales.Results: Patients reported a large number of complaints, a considerable presence of severe pain, and a clinically significant impact of disease on daily functioning. Most patients (92.4%) used medications, among which analgesics were the most prevalent. Fifty-six patients (70.9%) underwent surgery, including mainly interventions of the extremities and abdomen. Forty-one patients (51.9%) are currently enrolled in a physical therapy program, mainly comprising neuromuscular exercises, massage, and electrotherapy. Patients with a high consumption of analgesics, who visited the physiotherapist, or who underwent surgery had a higher dysfunction in daily life. Only 33.9% of the patients who underwent surgery and 63.4% of patients in physical therapy reported a positive outcome.Conclusions: Patients with EDS-HT have numerous complaints and an impaired functional status that strongly determine their high rate of treatment consumption. The outcome of surgical and physiotherapy treatment is disappointing in a large percentage, which illustrates a strong need for evidence-based therapy.