Neckties and Cerebrovascular Reactivity in Young Healthy Males: A Pilot Randomised Crossover Trial
Neckties and Cerebrovascular Reactivity in Young Healthy Males: A Pilot Randomised Crossover Trial
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年轻健康男性的领带和脑血管反应性：一项试点随机交叉试验
DOI：
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发表时间：
2010
影响因子：
1.5
通讯作者：
M. Walters
中科院分区：
文献类型：
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作者：
M. Rafferty;T. Quinn;J. Dawson;M. Walters
背景领带可能通过压迫静脉回流而升高颅内压。我们假设一条紧领带会有害地改变脑血管反应性。材料和方法。使用定制的装置模拟领带，该装置包括具有膜盒压力计的气动内胎。使用随机交叉设计，在“伪领带”佩戴充气或放气5分钟（分别模拟紧/松领带）的情况下测量脑血管反应性。使用屏气指数（BHI）计算反应性，并使用配对“t”检验进行比较分析。结果我们招募了40名健康男性志愿者。“紧”假结扎组脑血管反应性降低0.23个单位（BHI松1.44（SD 0.48）; BHI紧1.21（SD 0.38）P <0.001）。结论在膨胀的假领带中发现脑血管反应性受损。然而，平均BHI仍在正常范围内。在有血管危险因素的患者中，情况可能不同，建议进行确认性工作。
Background. A necktie may elevate intracranial pressure through compression of venous return. We hypothesised that a tight necktie would deleteriously alter cerebrovascular reactivity. Materials and Methods. A necktie was simulated using bespoke apparatus comprising pneumatic inner-tube with aneroid pressure-gauge. Using a randomised crossover design, cerebrovascular reactivity was measured with the “pseudo-tie” worn inflated or deflated for 5 minutes (simulating tight/loose necktie resp.). Reactivity was calculated using breath hold index (BHI) and paired “t” testing used for comparative analysis. Results. We enrolled 40 healthy male volunteers. There was a reduction in cerebrovascular reactivity of 0.23 units with “tight” pseudotie (BHI loose 1.44 (SD 0.48); BHI tight 1.21 (SD 0.38) P < .001). Conclusion. Impairment in cerebrovascular reactivity was found with inflated pseudo-tie. However, mean BHI is still within a range of considered normal. The situation may differ in patients with vascular risk factors, and confirmatory work is recommended.