SPRINT Revisited: Updated Results and Implications.
SPRINT Revisited: Updated Results and Implications.
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DOI：
10.1161/hypertensionaha.121.17682
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发表时间：
2021-12
期刊：
影响因子：
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通讯作者：
SPRINT Research Group
中科院分区：
文献类型：
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作者：
Wright JT Jr;Whelton PK;Johnson KC;Snyder JK;Reboussin DM;Cushman WC;Williamson JD;Pajewski NM;Cheung AK;Lewis CE;Oparil S;Rocco MV;Beddhu S;Fine LJ;Cutler JA;Ambrosius WT;Rahman M;Still CH;Chen Z;Tatsuoka C;SPRINT Research Group
收缩压干预试验(SPRINT)的结果影响了临床实践，但也引发了关于该结果的有效性、概括性和重要性的讨论。继2015年Sprint初步结果手稿之后，对数据的更多结果和分析解决了这些关切。这份手稿的主要目的是回应提出的关键问题。收缩压干预试验(SPRINT)证明了将SBP治疗到远低于美国和欧洲BP指南先前推荐的水平的有效性。Sprint的结果已经通知了指南委员会，建议对低于先前建议的SBP目标进行治疗。然而，Sprint的一些发现引起了讨论，并对其在临床实践中的应用提出了质疑。这些因素包括可概括性、结果测量(尤其是心力衰竭)的有效性、用于确定事件的方法、干预效益的影响大小以及120毫米汞柱指标的安全性和耐受性。在Sprint于2015年发布初步结果之后，Sprint发布了更多报告，解决了其中许多问题。这篇手稿回顾了斯普林特研究结果的有效性和潜在的临床意义的证据。
The Systolic Blood Pressure Intervention Trial (SPRINT) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability and importance of the findings. Following the SPRINT primary results manuscript in 2015, additional results and analyses of the data have addressed these concerns. The primary objective of this manuscript is to respond to key questions that have been raised. The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated the effectiveness of treating SBP to levels well below those previously recommended in US and European BP guidelines. The SPRINT results have informed guideline committees in recommending treatment to SBP targets lower than previously advised. However, some of the SPRINT findings have generated discussion, and questions have been raised regarding their application in clinical practice. These include generalizability, validity of the outcome measures (especially heart failure), the methods used for event ascertainment, the effect size of the intervention benefit, and safety and tolerability of the <120 mmHg target. Following the SPRINT primary results publication in 2015, additional reports from SPRINT have addressed many of these concerns. This manuscript reviews evidence for validity and potential clinical implications of the SPRINT findings.