Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors
复制标题
DOI：
10.4238/gmr16018877
复制
发表时间：
2017-01-01
影响因子：
0.4
通讯作者：
Luo, L. P.
中科院分区：
文献类型：
--
作者：
Chen, Z. H.;Xian, J. F.;Luo, L. P.
谷胱甘肽S-转移酶（GST）是II相代谢酶的重要成员，GSTM 1、GSTT 1和GSTP 1属于GST酶的三个亚家族。GSTM 1、GSTT 1和GSTP 1的多态性可能影响解毒过程，并增加个体对癌症的易感性。本研究旨在探讨中国人群中GSTM 1、GSTT 1和GSTP 1基因多态性与胃癌发病风险的关系。此外，我们还研究了基因-环境相互作用的影响，以及它们对这种癌症风险的影响。在2013年7月至2015年6月期间，我们招募了242名胃癌患者和396名健康对照。聚合酶链反应-限制性片段长度多态性分析被用来描述GSTM 1，GSTT 1和GSTP 1的遗传多态性。我们观察到GSTP 1的瓦尔/瓦尔基因型与胃癌的风险增加（OR = 3.19，95%CI = 1.84-5.56）。GST P1的瓦尔等位基因与胃癌易感性的相关性高于Ile等位基因（OR = 1.52，95%CI = 1.19-1.93）。GSTM 1和GSTT 1基因多态性与胃癌的发生无关。总之，我们的研究表明，GSTP 1 Ile 105 Val，而不是GSTM 1和GSTT 1多态性，与胃癌的风险。
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of gastric cancer in a Chinese population. In addition, we also examined the effect of gene-environmental interactions, and their effect on risk of this cancer. Between July 2013 and June 2015, we recruited 242 gastric cancer patients and 396 healthy controls for our study. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to characterize genetic polymorphisms in GSTM1, GSTT1, and GSTP1. We observed that the Val/Val genotype of GSTP1 was associated with increased risk of gastric cancer when compared with the Ile/Ile genotype (OR = 3.19, 95%CI = 1.84-5.56). Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93). However, GSTM1 and GSTT1 polymorphisms did not affect the development of gastric cancer. In conclusion, our study indicated that GSTP1 Ile105Val, but not GSTM1 and GSTT1 polymorphisms, was associated with risk of gastric cancer.