Concentration-related effects of morphine on cognition and motor control in human subjects.
Concentration-related effects of morphine on cognition and motor control in human subjects.
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发表时间：
1991-11
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通讯作者：
Beth Kerr;Harlan F. Hill;B. Coda;M. Calogero;C. Chapman;Earl Hunt;V. Buffington;A. Mackie
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作者：
Beth Kerr;Harlan F. Hill;B. Coda;M. Calogero;C. Chapman;Earl Hunt;V. Buffington;A. Mackie
吗啡和其他阿片类镇痛药可能会干扰正常的认知和运动功能，当药物用于长期治疗疼痛。我们使用个体定制的稳态药物输注来确定健康志愿者中μ受体选择性阿片类吗啡的认知和运动效应的性质和程度。量身定制的输注允许评估每名受试者在三个连续、恒定的吗啡血浆浓度下的认知和运动影响。与在单独的生理盐水输注日获得的功能评估相比，输注吗啡至通常用于镇痛的治疗范围内的血浆浓度导致认知和运动功能的一些但非所有要素的显著损害。在吗啡输注过程中，编码和处理连续呈现的言语信息所需的时间增加，维持低一致水平力量的能力下降。我们还评估了吗啡和生理盐水输注后3小时的口头回忆。延迟回忆的信息在吗啡输注过程中显着受损。我们的研究结果表明，吗啡可以干扰认知和运动性能的血浆药物浓度在通常的治疗范围内。
Morphine and other opioid analgesics may interfere with normal cognition and motor function when the drugs are used for long-term treatment of pain. We used individually tailored steady-state drug infusions to identify the nature and extent of cognitive and motor effects of the mu-receptor-selective opioid morphine in healthy volunteers. The tailored infusions allowed evaluation of cognitive and motor effects at three sequential, constant plasma concentrations of morphine in each subject. Compared with functional assessments obtained in a separate saline infusion day, infusions of morphine to plasma concentrations in the usual therapeutic range for analgesia caused significant impairments of some but not all elements of cognitive and motor function. The time needed to encode and process serially presented verbal information increased and the ability to maintain low consistent levels of force decreased during the morphine infusion. We also assessed verbal recall 3 hours after the morphine and saline infusions. Delayed recall of information presented during the morphine infusion was significantly impaired. Our results demonstrate that morphine can interfere with cognitive and motor performance at plasma drug concentrations within the usual therapeutic range.