Cancer risk assessment at the atomic level
Cancer risk assessment at the atomic level
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DOI：
10.1158/0008-5472.can-05-3034
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发表时间：
2006-02-15
期刊：
影响因子：
11.2
通讯作者：
Couch, FJ
中科院分区：
文献类型：
--
作者：
Monteiro, ANA;Couch, FJ
一系列关于BRCA1和BRCA2不同结构域结构的文章不仅揭示了这些蛋白质的生物学，而且还提出了希望，即这些数据最终可以用于推断大量遗传性错义突变的癌症关联，这些突变对蛋白质功能的影响尚不清楚。
A flurry of articles on the structure of different domains of BRCA1 and BRCA2 have not only shed light on the biology of these proteins but have also raised hopes that these data could eventually be used to infer cancer association for a large number of inherited missense mutations whose effect on protein function is unclear.