The Neural System of Postdecision Evaluation in Rostral Frontal Cortex during Problem-solving Tasks.
The Neural System of Postdecision Evaluation in Rostral Frontal Cortex during Problem-solving Tasks.
复制标题
解决问题任务期间头侧额叶皮层决策后评估的神经系统
DOI：
10.1523/eneuro.0188-16.2016
复制
发表时间：
2016-07
期刊：
影响因子：
3.4
通讯作者：
Tanaka K
中科院分区：
文献类型：
--
作者：
Wan X;Cheng K;Tanaka K
在没有明确反馈的任务范式下的fMRI研究中，对决策后加工的研究较少受到关注。尽管在对视觉呈现的词汇做出熟悉而新颖的决定后，先前在外侧额叶皮质观察到了迟发的大胆反应，但导致迟发的大胆反应的神经激活的本质仍然难以捉摸。我们在这里发现，在其专业领域内执行复杂问题解决任务的人类专家，包括外侧额叶皮质在内的头侧额叶皮质，以及前下顶叶，只有在决策后阶段才被激活，尽管没有反馈。也就是说，这些区域表现出迟发性的大胆反应，用不同的模型对这些大胆反应进行拟合表明，它们是由决策后发生的神经激活引起的。然而，在执行感觉-运动控制任务后没有反应， 决策后激活的大小与对先前决策的不确定性程度相关，这表明决策后神经激活与之前的决策过程有关。此外，当受试者明确地重新思考前面的问题时，同一组区域被更强烈地激活。这些结果表明，在决策后评估中，头侧额叶皮质和顶下前小叶构成了一个不确定性监测和探索替代解决方案的网络。因此，目前的结果介绍了一个新的方面的功能梯度沿吻尾轴在额叶皮质。
Little attention has been paid to the postdecision processing in fMRI studies with task paradigms in which there was no explicit feedback. Although late-onset BOLD responses were previously observed in the lateral frontopolar cortex after the familiar-novel decision on visually presented words, the nature of neural activations that caused the late-onset BOLD responses remained elusive. We here found, in human experts conducting complicated problem-solving tasks in their expertise domain, that the rostral frontal cortex, including the lateral frontopolar cortex, along with the anterior inferior parietal lobule, was activated only during the postdecision period, although there was no feedback. That is, these areas showed late-onset BOLD responses, and fitting of the BOLD responses with different models indicates that they were caused by neural activations that occurred after the decision. However, there was no response after performing a sensory-motor control task, and the magnitude of postdecision activations was correlated with the degree of uncertainty about the preceding decision, which suggests that the postdecision neural activations were associated with the preceding decision procedure. Furthermore, the same set of areas was more strongly activated when the subject explicitly rethought the preceding problem. These results suggest that the rostral frontal cortex, together with anterior inferior parietal lobule, comprises a network for uncertainty monitoring and exploration of alternative resolutions in postdecision evaluation. The present results thus introduce a new aspect of the functional gradient along the rostrocaudal axis in the frontal cortex.