PLASMA KININ AND KININOGEN LEVELS IN THE FEMALE RAT DURING THE OESTROUS CYCLE, PREGNANCY, PARTURITION AND THE PUERPERIUM
PLASMA KININ AND KININOGEN LEVELS IN THE FEMALE RAT DURING THE OESTROUS CYCLE, PREGNANCY, PARTURITION AND THE PUERPERIUM
复制标题
雌性大鼠在发情周期、妊娠、分娩和产褥期血浆激肽和激肽原水平
DOI：
--
复制
发表时间：
1974
影响因子：
7.3
通讯作者：
J. Senior
中科院分区：
文献类型：
--
作者：
J. McCORMICK;J. Senior
1雌性大鼠血浆激肽原浓度在发情周期内没有变化，但在妊娠期间增加了一倍。血浆激肽原在分娩过程中无变化，产后第1天升高，然后迅速下降至非妊娠水平。2未孕雌性大鼠血中游离激动素水平低且不稳定。在怀孕大鼠的血液中没有检测到游离激动素，但在十分之四的分娩大鼠中发现了游离激动素。3肌注激氨酸酶抑制剂二硫丙醇(30 mg/kg)后，6只临产大鼠血液中均有游离激动素存在。在6只未怀孕的大鼠中，只有1只在血液中出现了游离激动素。4分娩过程中血浆激肽系统似乎有一定程度的激活。
1 Plasma kininogen concentration of the female rat did not change during the oestrous cycle but increased two‐fold during gestation. Plasma kininogen did not change during parturition, rose in the first puerperal day and then rapidly declined to non‐pregnant levels. 2 Free kinin levels in the blood of non‐pregnant female rats were low and inconstant. Free kinin was undetectable in the blood of pregnant rats, but was found in four out of ten parturient rats. 3 After administration of the kininase inhibitor dimercaprol (30 mg/kg i.p.), free kinin was present in the blood of six parturient rats. Dimercaprol caused appearance of free kinin in the blood of only one out of six non‐pregnant rats. 4 It appears that the plasma kinin system is activated to a small degree during parturition.